BEX3 and MIF

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		BEX3	MIF
Description		brain expressed X-linked 3	macrophage migration inhibitory factor
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell Surface Vesicle Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Signaling Receptor Binding Nerve Growth Factor Receptor Binding Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Identical Protein Binding Metal Ion Binding	Dopachrome Isomerase Activity Cytokine Activity Cytokine Receptor Binding Protein Binding Chemoattractant Activity Identical Protein Binding Phenylpyruvate Tautomerase Activity
	Biological Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Multicellular Organism Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Prostaglandin Biosynthetic Process Positive Regulation Of Cytokine Production Inflammatory Response Cell Surface Receptor Signaling Pathway Negative Regulation Of Gene Expression Positive Regulation Of Protein Kinase A Signaling Negative Regulation Of Macrophage Chemotaxis Carboxylic Acid Metabolic Process Negative Regulation Of Cell Migration Positive Regulation Of B Cell Proliferation Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Innate Immune Response Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Regulation Of Cell Cycle Protein Homotrimerization Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Aging Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Pathways		NADE modulates death signalling	Cell surface interactions at the vascular wall Neutrophil degranulation Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs			3,4-Dihydroxycinnamic Acid 7-Hydroxy-2-Oxo-Chromene-3-Carboxylic Acid Ethyl Ester 4-Hydroxyphenylpyruvic acid 3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTER 4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME 3-FLUORO-4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME 4-HYDROXYBENZALDEHYDE O-(3,3-DIMETHYLBUTANOYL)OXIME 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE
Diseases
GWAS			Alanine aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Macrophage Migration Inhibitory Factor levels ( 27989323) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		42 interacting genes: AIMP2 AKAP8L BFSP2 CACYBP CBY2 CCDC116 CCDC85B CTNNBL1 DIABLO EMILIN1 ENKD1 FSD2 GOLGA8EP GOLGA8F ING4 ING5 KRT34 MCCD1 MDFI MIF MNAT1 NECAB2 NGFR NTRK3 PTPN13 S100A1 S100Z SIVA1 SMARCD1 SMPD1 TACC3 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TSNAX USHBP1 VTA1 YWHAE ZNF417	15 interacting genes: BEX3 BNIPL CD74 COPS5 COPS6 EGFR FCER1G GNAL GORASP2 NME1 NTAQ1 STRN4 TP53 UPF2 ZNF408
Entrez ID		27018	4282
HPRD ID		02291	01091
Ensembl ID		ENSG00000166681	ENSG00000240972
Uniprot IDs		Q00994	I4AY87 P14174
PDB IDs		1SA6	1CA7 1CGQ 1GCZ 1GD0 1GIF 1LJT 1MIF 1P1G 2OOH 2OOW 2OOZ 3B9S 3CE4 3DJH 3DJI 3HOF 3IJG 3IJJ 3JSF 3JSG 3JTU 3L5P 3L5R 3L5S 3L5T 3L5U 3L5V 3SMB 3SMC 3U18 3WNR 3WNS 3WNT 4ETG 4EUI 4EVG 4F2K 4GRN 4GRO 4GRP 4GRQ 4GRR 4GRU 4GUM 4K9G 4OSF 4OYQ 4P01 4P0H 4PKK 4PKZ 4PLU 4TRF 4TRU 4WR8 4WRB 4XX7 4XX8 4Z15 4Z1T 4Z1U 5B4O 5BS9 5BSC 5BSI 5BSJ 5EIZ 5HVS 5HVT 5HVV 5J7P 5J7Q 5UMJ 5UMK 5UZY 5V70 5V73 5XEJ 6B1C 6B1K 6B2C 6BG6 6BG7 6CB5 6CBF 6CBG 6CBH 6FVE 6FVH 6OY8 6OYB 6OYE 6OYG 6PEG
Enriched GO Terms of Interacting Partners?
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