TIAM2 and UFD1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		TIAM2	UFD1
Description		TIAM Rac1 associated GEF 2	ubiquitin recognition factor in ER associated degradation 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Membrane Lamellipodium Filopodium Growth Cone Perikaryon Synapse Extracellular Exosome	Nucleus Nucleoplasm Cytosol VCP-NPL4-UFD1 AAA ATPase Complex UFD1-NPL4 Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity	Thiol-dependent Deubiquitinase Signaling Receptor Binding Protein Binding Polyubiquitin Modification-dependent Protein Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Protein-containing Complex Binding ATPase Binding
	Biological Process	Small GTPase Mediated Signal Transduction Positive Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity	Skeletal System Development Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Type I Interferon Production Negative Regulation Of RIG-I Signaling Pathway ER-associated Misfolded Protein Catabolic Process
Pathways		NRAGE signals death through JNK PPARA activates gene expression G alpha (12/13) signalling events RAC1 GTPase cycle	Translesion Synthesis by POLH Ub-specific processing proteases
Drugs
Diseases
GWAS		Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Asthma ( 31361310) Dimensional psychopathology (Arousal) ( 29496196) Dimensional psychopathology (Negative) ( 29496196) Heel bone mineral density ( 30598549) Lipoprotein (a) levels ( 26377243) Triiodothyronine levels and thyroxine levels ( 30843173)
Interacting Genes		9 interacting genes: ANXA7 DISC1 DNM2 H2AX PARD3 SH3GL2 TK1 TNIK UFD1	23 interacting genes: A2M AMFR ANAPC2 CHMP2A F13A1 GZMK HSPB1 IGHM LRRK2 MAP3K1 MASP1 NGFR NPLOC4 NUB1 PIK3CA PPHLN1 SNX1 TAF1C TIAM2 TP53 UBC UBXN6 VCP
Entrez ID		26230	7353
HPRD ID		05273	06778
Ensembl ID		ENSG00000146426	ENSG00000070010
Uniprot IDs		B3KW11 Q8IVF5	Q541A5 Q92890
PDB IDs			2YUJ 5B6C 5C1B
Enriched GO Terms of Interacting Partners?
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