GATA1 and CCDC24

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, two hybrid)

		GATA1	CCDC24
Description		GATA binding protein 1	coiled-coil domain containing 24
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Transcription Repressor Complex Protein-DNA Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Chromatin DNA Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding C2H2 Zinc Finger Domain Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of Transcription By RNA Polymerase II Cell-cell Signaling Negative Regulation Of Cell Population Proliferation Male Gonad Development Regulation Of Glycoprotein Biosynthetic Process Regulation Of Definitive Erythrocyte Differentiation Regulation Of Primitive Erythrocyte Differentiation Erythrocyte Differentiation Megakaryocyte Differentiation Platelet Formation Basophil Differentiation Eosinophil Differentiation Negative Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Proliferation Embryonic Hemopoiesis Eosinophil Fate Commitment Negative Regulation Of Apoptotic Process Cell Fate Commitment Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Erythrocyte Development Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Peptidyl-tyrosine Phosphorylation Platelet Aggregation Dendritic Cell Differentiation Cellular Response To Thyroid Hormone Stimulus Negative Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Blastocyst Hatching
Pathways		RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494)	Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		85 interacting genes: AKT1 ARID1A ARMC7 ATP6V0D1 BCL6 CASP3 CCDC24 CEBPE CHRD CREBBP DGCR6L DNMT3L FANCG FANCL FBF1 FHL3 FLI1 FRS3 GLRX3 GOLGA2 GRAP2 HDAC3 HDAC4 HDAC5 HEMGN HEXIM2 HEY1 HOXA1 HSPA4 KANK2 KRTAP10-5 KRTAP3-2 KRTAP4-11 KRTAP4-5 KRTAP9-2 LMO2 LZTS2 MAPK1 MAPK3 MAPK6 MDFI MED1 MGAT5B MKRN3 PITX1 PLSCR4 PML PNMA1 PPP1R16B PRKAA1 PRKAB2 PSMF1 RADIL RAI1 RBPMS RIN3 SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCE1 SP1 SPI1 SPIB SRA1 STAT3 TAF7 TAL1 TAX1BP3 TEKT4 TLE5 TNS2 TRAF1 TRIM25 TRIM29 TRIP6 USP7 ZBTB16 ZBTB22 ZDHHC17 ZFPM1 ZFPM2 ZNF521 ZZZ3	39 interacting genes: ADRA2C AKAP8L ANTKMT ARMH1 CDC23 DISC1 DYNLT4 FAM166B FNTB GATA1 HPDL HYI IKZF3 KLF17 KRT33B KRT34 KRTAP13-2 KRTAP15-1 KRTAP19-1 KRTAP19-6 KRTAP19-7 KRTAP6-1 KRTAP6-3 LRP2BP MAGEA6 NDUFAB1 NDUFB7 OIP5 REN RNF31 TCEAL8 TRIM42 TRIP6 TTC23 TTC23L USHBP1 USP54 WWOX ZMYND12
Entrez ID		2623	149473
HPRD ID		02372	14636
Ensembl ID		ENSG00000102145	ENSG00000159214
Uniprot IDs		P15976	Q8N4L8
PDB IDs		6G0Q
Enriched GO Terms of Interacting Partners?
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