CCDC24 and GATA1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, two hybrid)

		CCDC24	GATA1
Description		coiled-coil domain containing 24	GATA binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component		Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Transcription Repressor Complex Protein-DNA Complex
	Molecular Function	Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Chromatin DNA Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding C2H2 Zinc Finger Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Blastocyst Hatching	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of Transcription By RNA Polymerase II Cell-cell Signaling Negative Regulation Of Cell Population Proliferation Male Gonad Development Regulation Of Glycoprotein Biosynthetic Process Regulation Of Definitive Erythrocyte Differentiation Regulation Of Primitive Erythrocyte Differentiation Erythrocyte Differentiation Megakaryocyte Differentiation Platelet Formation Basophil Differentiation Eosinophil Differentiation Negative Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Proliferation Embryonic Hemopoiesis Eosinophil Fate Commitment Negative Regulation Of Apoptotic Process Cell Fate Commitment Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Erythrocyte Development Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Peptidyl-tyrosine Phosphorylation Platelet Aggregation Dendritic Cell Differentiation Cellular Response To Thyroid Hormone Stimulus Negative Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026)	Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494)
Interacting Genes		39 interacting genes: ADRA2C AKAP8L ANTKMT ARMH1 CDC23 DISC1 DYNLT4 FAM166B FNTB GATA1 HPDL HYI IKZF3 KLF17 KRT33B KRT34 KRTAP13-2 KRTAP15-1 KRTAP19-1 KRTAP19-6 KRTAP19-7 KRTAP6-1 KRTAP6-3 LRP2BP MAGEA6 NDUFAB1 NDUFB7 OIP5 REN RNF31 TCEAL8 TRIM42 TRIP6 TTC23 TTC23L USHBP1 USP54 WWOX ZMYND12	85 interacting genes: AKT1 ARID1A ARMC7 ATP6V0D1 BCL6 CASP3 CCDC24 CEBPE CHRD CREBBP DGCR6L DNMT3L FANCG FANCL FBF1 FHL3 FLI1 FRS3 GLRX3 GOLGA2 GRAP2 HDAC3 HDAC4 HDAC5 HEMGN HEXIM2 HEY1 HOXA1 HSPA4 KANK2 KRTAP10-5 KRTAP3-2 KRTAP4-11 KRTAP4-5 KRTAP9-2 LMO2 LZTS2 MAPK1 MAPK3 MAPK6 MDFI MED1 MGAT5B MKRN3 PITX1 PLSCR4 PML PNMA1 PPP1R16B PRKAA1 PRKAB2 PSMF1 RADIL RAI1 RBPMS RIN3 SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCE1 SP1 SPI1 SPIB SRA1 STAT3 TAF7 TAL1 TAX1BP3 TEKT4 TLE5 TNS2 TRAF1 TRIM25 TRIM29 TRIP6 USP7 ZBTB16 ZBTB22 ZDHHC17 ZFPM1 ZFPM2 ZNF521 ZZZ3
Entrez ID		149473	2623
HPRD ID		14636	02372
Ensembl ID		ENSG00000159214	ENSG00000102145
Uniprot IDs		Q8N4L8	P15976
PDB IDs			6G0Q
Enriched GO Terms of Interacting Partners?
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