UPF2 and PHB2

Number of citations of the paper that reports this interaction (PubMedID 15231747)
57

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		UPF2	PHB2
Description		UPF2 regulator of nonsense mediated mRNA decay	prohibitin 2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Polysome Exon-exon Junction Complex Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Plasma Membrane Cell Surface Postsynaptic Density Nuclear Matrix Axon Protein-containing Complex Mitochondrial Prohibitin Complex Presynaptic Active Zone Cell Periphery Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	RNA Binding Protein Binding Telomeric DNA Binding	Protein Binding Protein C-terminus Binding Estrogen Receptor Binding Amide Binding Identical Protein Binding Protein Homodimerization Activity Sphingolipid Binding Protein Heterodimerization Activity Protein N-terminus Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Liver Development MRNA Export From Nucleus Animal Organ Regeneration	Mitophagy Positive Regulation Of Immunoglobulin Production Protein Import Into Nucleus Mitochondrion Organization Sister Chromatid Cohesion Activation Of Phospholipase C Activity Response To Wounding Cell Migration CD40 Signaling Pathway Regulation Of Complement Activation Positive Regulation Of Exit From Mitosis Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Induction By Virus Of Host Autophagy RIG-I Signaling Pathway B Cell Activation Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Mammary Gland Branching Involved In Thelarche Mammary Gland Alveolus Development Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Cellular Response To Hypoxia Antiviral Innate Immune Response Regulation Of Cardiolipin Metabolic Process Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Cytochrome-c Oxidase Activity Activation Of Protein Kinase C Activity
Pathways		Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Processing of SMDT1
Drugs			Capsaicin Rocaglamide Didesmethylrocaglamide
Diseases
GWAS		Diverticular disease ( 30177863)	Glycated hemoglobin levels ( 34059833 28898252) Red blood cell fatty acid levels ( 25500335) Refractive error ( 32231278)
Interacting Genes		78 interacting genes: ABCF2 AGPAT1 AKTIP ART4 ATP1B3 BLM CALR CENPU CIZ1 COMTD1 CYBA DCP1B DCP2 DPF2 E4F1 EIF1 EIF4A1 EIF4G1 ENO1 EXOSC1 EXOSC10 EXOSC4 EXOSC6 EXOSC8 GADD45GIP1 GATA3 HBZ HMGA1 HS3ST3A1 HSF2BP ITGB1 KRT18 LDHA LSM1 MAP1A MAP1LC3B MIF MRPL40 MTERF3 MTREX MYB NDUFA7 NOB1 NOMO1 NOP53 PHB2 PITX1 PUF60 RNPS1 RPL13 RPL5 RPL8 RPS15 RPS25 RPS6 RPS7 RRP7A RSRC2 SERBP1 SERF2 SMG1 SSBP2 SUMO3 TK1 TNNI2 TOP3B TUBB2A TYMS UPF1 UPF3B WNK1 XRN1 XRN2 ZBTB48 ZFP36 ZGPAT ZNF408 ZNF44	24 interacting genes: AFP AKT1 CDC42 ESR1 EZH2 FHL2 HDAC1 HDAC2 HDAC3 HDAC5 MAP1LC3A MEF2A MRPS18B MYOD1 NR2F1 NR2F2 PPARG PPP1CA PRKCA PTEN PTMA RNF2 TEAD3 UPF2
Entrez ID		26019	11331
HPRD ID		10405	17843
Ensembl ID		ENSG00000151461	ENSG00000215021
Uniprot IDs		Q9HAU5	Q99623
PDB IDs		1UW4 2WJV 4CEK 4CEM	6IQE
Enriched GO Terms of Interacting Partners?
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