PHB2 and PTMA

Number of citations of the paper that reports this interaction (PubMedID 12943695)
12

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		PHB2	PTMA
Description		prohibitin 2	prothymosin alpha
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Plasma Membrane Cell Surface Postsynaptic Density Nuclear Matrix Axon Protein-containing Complex Mitochondrial Prohibitin Complex Presynaptic Active Zone Cell Periphery Glutamatergic Synapse GABA-ergic Synapse	Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Binding Protein C-terminus Binding Estrogen Receptor Binding Amide Binding Identical Protein Binding Protein Homodimerization Activity Sphingolipid Binding Protein Heterodimerization Activity Protein N-terminus Binding	Protein Binding DNA-binding Transcription Factor Binding
	Biological Process	Mitophagy Positive Regulation Of Immunoglobulin Production Protein Import Into Nucleus Mitochondrion Organization Sister Chromatid Cohesion Activation Of Phospholipase C Activity Response To Wounding Cell Migration CD40 Signaling Pathway Regulation Of Complement Activation Positive Regulation Of Exit From Mitosis Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Induction By Virus Of Host Autophagy RIG-I Signaling Pathway B Cell Activation Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Mammary Gland Branching Involved In Thelarche Mammary Gland Alveolus Development Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Cellular Response To Hypoxia Antiviral Innate Immune Response Regulation Of Cardiolipin Metabolic Process Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Cytochrome-c Oxidase Activity Activation Of Protein Kinase C Activity	Transcription, DNA-templated Negative Regulation Of Apoptotic Process
Pathways		Processing of SMDT1
Drugs		Capsaicin Rocaglamide Didesmethylrocaglamide
Diseases
GWAS		Glycated hemoglobin levels ( 34059833 28898252) Red blood cell fatty acid levels ( 25500335) Refractive error ( 32231278)	Eating disorders (purging via substances) ( 23568457) Height ( 18391951) Lymphocyte counts ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494 27863252)
Interacting Genes		24 interacting genes: AFP AKT1 CDC42 ESR1 EZH2 FHL2 HDAC1 HDAC2 HDAC3 HDAC5 MAP1LC3A MEF2A MRPS18B MYOD1 NR2F1 NR2F2 PPARG PPP1CA PRKCA PTEN PTMA RNF2 TEAD3 UPF2	44 interacting genes: CASP3 CASP7 CCNA2 CCNB1 CDK1 CDK2 CDK4 CREBBP EP300 ESR1 GSK3A H1-1 H2AC14 H2BC21 H2BC8 H3-4 H3C14 H4C1 H4C14 HDAC1 HDAC2 HSPA1A IL7R KEAP1 KPNA2 KPNB1 NCOR1 NUP62 NUPR1 NUTF2 PCNA PHB2 PTPN2 RAN RCC1 SET SIN3A STAT3 TERF1 TERF2 TERF2IP TERT VIPR1 ZDHHC17
Entrez ID		11331	5757
HPRD ID		17843	01778
Ensembl ID		ENSG00000215021	ENSG00000187514
Uniprot IDs		Q99623	P06454 Q53S24
PDB IDs		6IQE	2L9I 2MNQ
Enriched GO Terms of Interacting Partners?
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