WWTR1 and PRRG2

Number of citations of the paper that reports this interaction (PubMedID 23873930)
7

Data Source:
BioGRID (pull down)

		WWTR1	PRRG2
Description		WW domain containing transcription regulator 1	proline rich and Gla domain 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Plasma Membrane Nuclear Body	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein Homodimerization Activity	Calcium Ion Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Tissue Homeostasis Negative Regulation Of Protein Phosphorylation Heart Process Regulation Of Transcription, DNA-templated Negative Regulation Of Protein Kinase Activity Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Protein Ubiquitination Stem Cell Division SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Glomerulus Development Multicellular Organism Growth Hippo Signaling Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Mesenchymal Cell Differentiation Cilium Assembly Regulation Of SMAD Protein Signal Transduction Kidney Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Localization To Nucleus
Pathways		Signaling by Hippo YAP1- and WWTR1 (TAZ)-stimulated gene expression YAP1- and WWTR1 (TAZ)-stimulated gene expression SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Physiological factors RUNX2 regulates osteoblast differentiation RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases
GWAS		Height ( 31562340) Polycystic ovary syndrome ( 32289280) Preeclampsia ( 23551011) Triglyceride levels ( 34074324)	Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Iron status biomarkers (total iron binding capacity) ( 33536631) Red blood cell count ( 32888494 27863252) Schizophrenia ( 25056061 29483656 30285260)
Interacting Genes		26 interacting genes: C1orf74 DAPK1 IL16 LATS1 LATS2 MFHAS1 NKX2-1 PAX3 PLOD2 PPP1CA PRRG2 PRRG4 RTN4IP1 RUNX1 SLC9A3R2 SUMO3 TCP11L1 TEAD1 TEAD2 TEAD3 TEAD4 USP10 WBP2 YWHAE YWHAG YWHAZ	14 interacting genes: CCL4 CRK CYTH2 FAM221A FATE1 NEDD4 NEDD4L NKG7 PPP2R1A RTN4RL1 SGTA SNX15 WWTR1 YAP1
Entrez ID		25937	5639
HPRD ID		09580	09189
Ensembl ID		ENSG00000018408	ENSG00000126460
Uniprot IDs		Q9GZV5	O14669
PDB IDs		5N5R 5N5T 5N5W 5N75 6RHC 6RJL 6RJQ 6RP6 6SLW 6SLX
Enriched GO Terms of Interacting Partners?
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