ASF1A and TLK2

Number of citations of the paper that reports this interaction (PubMedID 11470414)
79

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		ASF1A	TLK2
Description		anti-silencing function 1A histone chaperone	tousled like kinase 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Protein-containing Complex	Nucleus Intermediate Filament Perinuclear Region Of Cytoplasm
	Molecular Function	Chromatin Binding Protein Binding Histone Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	Osteoblast Differentiation DNA Repair Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Muscle Cell Differentiation	Regulation Of Chromatin Assembly Or Disassembly Chromatin Organization Protein Phosphorylation Cellular Response To DNA Damage Stimulus Cell Cycle Chromosome Segregation Negative Regulation Of Autophagy Peptidyl-serine Phosphorylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Cellular Response To Gamma Radiation
Pathways		Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs			Fostamatinib
Diseases
GWAS		Mean platelet volume ( 32888494) Multiple sclerosis ( 31604244) QT interval ( 19305408)	Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Lifespan ( 25918517) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		33 interacting genes: ASF1B CHAF1A CHAF1B CHEK2 H3-3A H3-4 H3C3 H3C6 H4-16 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HIRA HTATIP2 MCM2 PAFAH1B2 PRR3 ST13 TAF1 TLK1 TLK2 VPS28 ZDHHC17	19 interacting genes: ASF1A ASF1B AURKA CEP70 DCAF7 DMAP1 DOCK1 FEZ1 FEZ2 FRMD6 GMCL1 IRF4 IRF7 MBP PAX5 PAX6 TLK1 UBE2I YWHAZ
Entrez ID		25842	11011
HPRD ID		16459	10527
Ensembl ID		ENSG00000111875	ENSG00000146872
Uniprot IDs		Q9Y294	B4DUC2 J3QLK5 Q86UE8
PDB IDs		1TEY 2I32 2IIJ 2IO5 3AAD 5C3I 6F0F 6F0G 6F0H	5O0Y
Enriched GO Terms of Interacting Partners?
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