COL7A1 and SHKBP1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
HPRD (two hybrid)

		COL7A1	SHKBP1
Description		collagen type VII alpha 1 chain	SH3KBP1 binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Type VII Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Collagen-containing Extracellular Matrix	Lysosome
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength	Protein Binding Identical Protein Binding
	Biological Process	Cell Adhesion Epidermis Development Negative Regulation Of Endopeptidase Activity Endodermal Cell Differentiation	Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Homooligomerization
Pathways		Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures COPII-mediated vesicle transport Integrin cell surface interactions Anchoring fibril formation Laminin interactions Laminin interactions Cargo concentration in the ER Collagen chain trimerization	CDC42 GTPase cycle
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 27089180) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 29875488) Bone fracture in osteoporosis ( 28580392) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Carotid intima media thickness (mean) ( 31801372) Cleft lip with or without cleft palate x maternal periconceptional smoking interaction (parent of origin effect) ( 31372216) Hemoglobin levels ( 32327693)
Interacting Genes		16 interacting genes: BMP1 COL1A1 COL4A1 FBXL2 FN1 HSPA8 LAMA1 LAMA5 LAMB3 LAMC2 MIA3 MMP2 NPHP3 SHKBP1 THBS1 ZC3H7A	12 interacting genes: CCNG1 COL7A1 CUL3 GRB2 HSP90AA1 HSP90AB1 LXN NR3C1 PIN1 PRPF3 SH3KBP1 YWHAG
Entrez ID		1294	92799
HPRD ID		00358	15338
Ensembl ID		ENSG00000114270	ENSG00000160410
Uniprot IDs		Q02388 Q59F16	B3KVX8 Q8TBC3
PDB IDs			4CRH
Enriched GO Terms of Interacting Partners?
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