SLC17A8 and CYP4F2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SLC17A8	CYP4F2
Description		solute carrier family 17 member 8	cytochrome P450 family 4 subfamily F member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Multivesicular Body Integral Component Of Membrane Integral Component Of Synaptic Vesicle Membrane Synaptic Vesicle Membrane Perikaryon Axon Terminus Excitatory Synapse Apical Dendrite Basal Dendrite Glial Limiting End-foot Pericellular Basket	Cytoplasm Endoplasmic Reticulum Membrane Apical Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	L-glutamate Transmembrane Transporter Activity Neurotransmitter Transmembrane Transporter Activity Symporter Activity Transmembrane Transporter Activity	Monooxygenase Activity Iron Ion Binding Protein Binding Arachidonic Acid Monooxygenase Activity Arachidonic Acid Epoxygenase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Alkane 1-monooxygenase Activity Heme Binding Leukotriene-B4 20-monooxygenase Activity Arachidonic Acid Omega-hydroxylase Activity Alpha-tocopherol Omega-hydroxylase Activity Tocotrienol Omega-hydroxylase Activity Aromatase Activity 20-hydroxy-leukotriene B4 Omega Oxidase Activity 20-aldehyde-leukotriene B4 20-monooxygenase Activity Docosanoate Omega-hydroxylase Activity
	Biological Process	Neural Retina Development Ion Transport Sodium Ion Transport Anion Transport Brain Development Sensory Perception Of Sound L-glutamate Transmembrane Transport Synaptic Transmission, Glutamatergic Regulation Of Synapse Structure Or Activity Cochlea Development Neurotransmitter Loading Into Synaptic Vesicle	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Renal Water Homeostasis Pressure Natriuresis Icosanoid Metabolic Process Leukotriene Metabolic Process Xenobiotic Metabolic Process Blood Coagulation Regulation Of Blood Pressure Arachidonic Acid Metabolic Process Epoxygenase P450 Pathway Negative Regulation Of Icosanoid Secretion Positive Regulation Of Icosanoid Secretion Leukotriene B4 Catabolic Process Vitamin E Metabolic Process Menaquinone Catabolic Process Phylloquinone Catabolic Process Vitamin K Catabolic Process Sodium Ion Homeostasis Omega-hydroxylase P450 Pathway
Pathways		Organic anion transporters Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) Sensory processing of sound by inner hair cells of the cochlea	Fatty acids Miscellaneous substrates Eicosanoids Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
Drugs
Diseases
GWAS		Low density lipoprotein cholesterol levels ( 32154731) Squamous cell carcinoma ( 23341777)	Acenocoumarol maintenance dosage ( 19578179) Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Circulating phylloquinone levels ( 25411281) Metabolite levels ( 23281178) Response to Vitamin E supplementation ( 22437554) Serum metabolite levels ( 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Vitamin E levels ( 21729881) Warfarin maintenance dose ( 20833655 19300499)
Interacting Genes		4 interacting genes: CYP4F2 DNAJC5 TMEM120B YIPF6	37 interacting genes: - AQP6 CHMP2A CPLX4 CREB3 CREB3L1 DNAJC1 EBP ELOVL4 ERGIC3 FAM210B FCER1G GJA8 HSD17B13 JAGN1 LEPROTL1 MMD MTIF3 MUC1 PGRMC2 PLEKHO1 REEP2 REEP4 RETREG3 SCN3B SDHAF2 SLC10A6 SLC17A8 SLC19A3 SLC2A13 THAP4 TLCD4 TM4SF19 TMEM51 TMEM82 TMX2 UBE2I
Entrez ID		246213	8529
HPRD ID		10457	05112
Ensembl ID		ENSG00000179520	ENSG00000186115
Uniprot IDs		Q8NDX2	P78329
PDB IDs
Enriched GO Terms of Interacting Partners?
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