FRK and BNIP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		FRK	BNIP2
Description		fyn related Src family tyrosine kinase	BCL2 interacting protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Intracellular Anatomical Structure Nucleus Nucleoplasm Cytosol Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Azurophil Granule Lumen Specific Granule Lumen Extracellular Exosome	Nuclear Envelope Cytoplasm Cytosol Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding	GTPase Activator Activity Calcium Ion Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Cell Population Proliferation Peptidyl-tyrosine Phosphorylation Cell Differentiation Innate Immune Response	Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Catalytic Activity Response To Oxygen-glucose Deprivation
Pathways		Neutrophil degranulation Regulation of PTEN stability and activity	Myogenesis Myogenesis
Drugs		Dasatinib Regorafenib Fostamatinib Zanubrutinib
Diseases
GWAS		Age-related macular degeneration ( 21665990) Alanine aminotransferase levels ( 33547301 34315874) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 28724990) Aspartate aminotransferase levels ( 33547301 34315874) C-reactive protein levels ( 30388399) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 20686565) Choroid plexus volume ( 31530798) Chronotype ( 30696823) Cognitive decline rate in late mild cognitive impairment ( 26252872) Diastolic blood pressure ( 27841878) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) HDL cholesterol levels ( 32203549 30698716) High density lipoprotein cholesterol levels ( 33339817) HOMA-B (corrected for HOMA-IR) ( 30369944) LDL cholesterol ( 24097068 20686565) LDL cholesterol levels ( 32203549 28334899) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Longevity ( 30294719) Low density lipoprotein cholesterol levels ( 32154731) Photic sneeze reflex ( 27182965) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Total cholesterol levels ( 28334899) Urate levels ( 23263486)	Gut microbiota (bacterial taxa) ( 27723756)
Interacting Genes		7 interacting genes: BNIP2 EGFR KHDRBS1 PRDM1 RB1 SF3B4 SKAP2	56 interacting genes: ABHD4 AGPAT3 APOBEC3B ARHGAP1 ARHGAP8 BCL2 BNIP3 BNIP5 BNIPL CDC42 CHODL CPLX4 CREB3 CYB5R3 DESI2 DGAT2L6 DHRS1 EI24 ERLIN1 FAHD1 FAM209A FAM3C FATE1 FGFR1 FRK GORAB GPR152 GPX8 GRAMD2A GSC2 HSPA1B KCNK5 KLC1 LDLRAD1 LIME1 LMNA MEOX1 MEOX2 MYO5B NCBP1 OTX2 PEX12 PLEKHO1 RASGRP4 SFT2D2 SIN3A SLC35E3 SLC39A9 SLC7A14 SYT1 SYT2 TMEM237 TMPRSS2 TMX2 UPK1B YIF1A
Entrez ID		2444	663
HPRD ID		05954	04481
Ensembl ID		ENSG00000111816	ENSG00000140299
Uniprot IDs		P42685	J3KN59 Q12982
PDB IDs
Enriched GO Terms of Interacting Partners?
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