FKBP8 and RHEB

Number of citations of the paper that reports this interaction (PubMedID 17991864)
148

Data Source:
BioGRID (pull down, two hybrid)

		FKBP8	RHEB
Description		FKBP prolyl isomerase 8	Ras homolog, mTORC1 binding
Image
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Cytosol Membrane Integral Component Of Endoplasmic Reticulum Membrane Mitochondrial Membrane Protein-containing Complex	Golgi Membrane Spliceosomal Complex Lysosomal Membrane Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Postsynaptic Density Membrane Extracellular Exosome
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Identical Protein Binding Protein Folding Chaperone Metal Ion Binding Disordered Domain Specific Binding	Magnesium Ion Binding GTPase Activity Protein Binding GTP Binding GDP Binding Protein Kinase Binding
	Biological Process	Protein Peptidyl-prolyl Isomerization Cell Fate Specification Negative Regulation Of Protein Phosphorylation Protein Folding Apoptotic Process Smoothened Signaling Pathway Regulation Of Gene Expression Dorsal/ventral Neural Tube Patterning Positive Regulation Of BMP Signaling Pathway Multicellular Organism Growth Intracellular Signal Transduction Camera-type Eye Development Negative Regulation Of Apoptotic Process	Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Macroautophagy Positive Regulation Of TOR Signaling Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Cell Cycle Negative Regulation Of Cold-induced Thermogenesis Regulation Of Type B Pancreatic Cell Development
Pathways		Ub-specific processing proteases	Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs			Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases
GWAS		Plasma parathyroid hormone levels ( 30134803) Urinary potassium excretion ( 31409800)	Carboplatin disposition in epthelial ovarian cancer ( 29367611) Metabolite levels ( 23823483)
Interacting Genes		50 interacting genes: ANKMY2 ARHGEF5 ARL13B ATP13A2 BCL2 BCL2L1 BNIPL CD79A CIDEB CLCN1 CXCR2 CYB561 CYBRD1 EBP EGFR ELOVL4 ERBB2 ERGIC3 FAM174A FGF14 GPR37 JAGN1 MAPK14 MFSD14B MTOR OGT PEX12 PLN PPP3CA PSMC1 PSMD2 RETREG3 RHBDD2 RHEB SCN3B SHANK3 SLC10A6 SLC35A5 SLC35B1 SMO TERF1 TMEM14B TMEM254 TMEM31 TMEM43 TMEM45B TMEM80 TMX1 VHL ZFPL1	35 interacting genes: A2M APOE APPBP2 ARIH2 ATM ATR BNIP3 BNIP3L BRAF CENPE CREB3 ECSIT FKBP8 HTT MAPK15 MTOR NCAM1 NOS3 PDE6D PIGB PLD1 PPP1R3C PSEN1 PSEN2 PTPRN2 RABAC1 RAF1 RNF152 RPS6KB1 RPTOR TRIM55 TRIM63 TSC1 TSC2 USP4
Entrez ID		23770	6009
HPRD ID		05327	03188
Ensembl ID		ENSG00000105701	ENSG00000106615
Uniprot IDs		A0A024R7P2 B2R8G6 Q14318	A0A090N900 Q15382
PDB IDs		2AWG 2D9F 2F2D 2MF9 3EY6 5MGX	1XTQ 1XTR 1XTS 3SEA 3T5G 5YXH 6BCU 6BSX 6BT0 7BTA 7BTC 7BTD
Enriched GO Terms of Interacting Partners?
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