IL17RA and IL17A

Number of citations of the paper that reports this interaction (PubMedID 9367539)
54

Data Source:
HPRD (in vivo, in vitro)

		IL17RA	IL17A
Description		interleukin 17 receptor A	interleukin 17A
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space External Side Of Plasma Membrane
	Molecular Function	Protein Binding Interleukin-17 Receptor Activity	Cytokine Activity Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Adaptive Immune Response Inflammatory Response Cell Surface Receptor Signaling Pathway Response To Virus Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Innate Immune Response Positive Regulation Of Inflammatory Response Fibroblast Activation Interleukin-17-mediated Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production	Positive Regulation Of Antimicrobial Peptide Production Adaptive Immune Response Apoptotic Process Inflammatory Response Immune Response Notch Signaling Pathway Cell-cell Signaling Cell Death Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-16 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Innate Immune Response Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Intestinal Epithelial Structure Maintenance Cellular Response To Interleukin-1 Fibroblast Activation Interleukin-17-mediated Signaling Pathway Granulocyte Migration Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
Pathways		Interleukin-17 signaling	Interleukin-17 signaling Interleukin-4 and Interleukin-13 signaling
Drugs			Secukinumab Ixekizumab
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Granulocyte percentage of myeloid white cells ( 27863252) Heschl's gyrus morphology ( 25130324) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) White blood cell count ( 32888494 27863252)	Height ( 28552196)
Interacting Genes		7 interacting genes: BCL2L13 BID IL17A MTDH POTEH PTPRT TESK1	3 interacting genes: DPH2 IL17RA KCNIP4
Entrez ID		23765	3605
HPRD ID		10399	04396
Ensembl ID		ENSG00000177663	ENSG00000112115
Uniprot IDs		Q96F46	Q16552
PDB IDs		3JVF 4HSA 4NUX 5N9B 5NAN	2VXS 4HR9 4HSA 4QHU 5HHV 5HHX 5HI3 5HI4 5HI5 5N7W 5N92 5NAN 5VB9 6WIO 6WIR
Enriched GO Terms of Interacting Partners?
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