IL17A and KCNIP4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		IL17A	KCNIP4
Description		interleukin 17A	potassium voltage-gated channel interacting protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space External Side Of Plasma Membrane	Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex
	Molecular Function	Cytokine Activity Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Voltage-gated Ion Channel Activity Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity
	Biological Process	Positive Regulation Of Antimicrobial Peptide Production Adaptive Immune Response Apoptotic Process Inflammatory Response Immune Response Notch Signaling Pathway Cell-cell Signaling Cell Death Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-16 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Innate Immune Response Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Intestinal Epithelial Structure Maintenance Cellular Response To Interleukin-1 Fibroblast Activation Interleukin-17-mediated Signaling Pathway Granulocyte Migration Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production	Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport
Pathways		Interleukin-17 signaling Interleukin-4 and Interleukin-13 signaling	Phase 1 - inactivation of fast Na+ channels
Drugs		Secukinumab Ixekizumab
Diseases
GWAS		Height ( 28552196)	Cadmium levels ( 26025379) Colorectal cancer ( 29228715) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 26169577) Diverticular disease ( 30177863) Lingual gyrus volume ( 31530798) Obesity-related traits ( 23251661) Parkinson disease and lewy body pathology ( 25663231) Post bronchodilator FEV1/FVC ratio ( 26634245) Postburn scar height ( 30595539) Rheumatoid arthritis ( 21156761) Suicidal ideation ( 20877300)
Interacting Genes		3 interacting genes: DPH2 IL17RA KCNIP4	11 interacting genes: APP ASPH COL1A2 GOLGA7 IL17A KCND2 LITAF MEOX2 PSEN1 PSEN2 TRH
Entrez ID		3605	80333
HPRD ID		04396	12184
Ensembl ID		ENSG00000112115	ENSG00000185774
Uniprot IDs		Q16552	A8K4N3 Q6PIL6
PDB IDs		2VXS 4HR9 4HSA 4QHU 5HHV 5HHX 5HI3 5HI4 5HI5 5N7W 5N92 5NAN 5VB9 6WIO 6WIR
Enriched GO Terms of Interacting Partners?
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