HSPBP1 and HSPA2

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1103

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, proximity labelling technology)
HPRD (two hybrid)

		HSPBP1	HSPA2
Description		HSPA (Hsp70) binding protein 1	heat shock protein family A (Hsp70) member 2
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GO Annotations	Cellular Component	Endoplasmic Reticulum	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Cytoplasm Cytosol Plasma Membrane Cell Surface Membrane CatSper Complex Extracellular Exosome Blood Microparticle Meiotic Spindle
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Enzyme Inhibitor Activity Protein Binding Ubiquitin Protein Ligase Binding	Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding Heat Shock Protein Binding Protein Folding Chaperone Tau Protein Binding Unfolded Protein Binding Chaperone Binding Misfolded Protein Binding Glycolipid Binding Disordered Domain Specific Binding
	Biological Process	Protein Folding Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Catalytic Activity	Positive Regulation Of Protein Phosphorylation Response To Unfolded Protein Male Meiotic Nuclear Division Male Meiosis I Spermatogenesis Spermatid Development Response To Heat Response To Cold Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Vesicle-mediated Transport Cellular Response To Unfolded Protein Protein Refolding Chaperone Cofactor-dependent Protein Refolding Synaptonemal Complex Disassembly Negative Regulation Of Inclusion Body Assembly Positive Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity
Pathways			Meiotic synapsis Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase
Drugs			Quercetin
Diseases
GWAS		Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		14 interacting genes: APP CLK1 EFEMP2 HSPA1A HSPA1B HSPA2 HSPA4 HSPA5 HSPA8 HSPA9 KRT27 LRIF1 NOTCH2NLA PTEN	12 interacting genes: APP BAG4 CDK1 EWSR1 HSPBP1 MAP3K3 MEOX2 PARP1 RNF144A SAE1 TRIM38 UBE3A
Entrez ID		23640	3306
HPRD ID		09991	07174
Ensembl ID		ENSG00000133265	ENSG00000126803
Uniprot IDs		Q9NZL4	A0A024R6B5 P54652
PDB IDs		1XQR 1XQS	3I33 4FSV 5FPD 5FPE 5FPM 5FPN
Enriched GO Terms of Interacting Partners?
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