HSPA2 and RNF144A

Number of citations of the paper that reports this interaction (PubMedID 31406303)
14

Data Source:
BioGRID (pull down)

		HSPA2	RNF144A
Description		heat shock protein family A (Hsp70) member 2	ring finger protein 144A
Image
GO Annotations	Cellular Component	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Cytoplasm Cytosol Plasma Membrane Cell Surface Membrane CatSper Complex Extracellular Exosome Blood Microparticle Meiotic Spindle	Ubiquitin Ligase Complex Cytoplasm Golgi Apparatus Plasma Membrane Endosome Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding Heat Shock Protein Binding Protein Folding Chaperone Tau Protein Binding Unfolded Protein Binding Chaperone Binding Misfolded Protein Binding Glycolipid Binding Disordered Domain Specific Binding	Protein Binding Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Response To Unfolded Protein Male Meiotic Nuclear Division Male Meiosis I Spermatogenesis Spermatid Development Response To Heat Response To Cold Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Vesicle-mediated Transport Cellular Response To Unfolded Protein Protein Refolding Chaperone Cofactor-dependent Protein Refolding Synaptonemal Complex Disassembly Negative Regulation Of Inclusion Body Assembly Positive Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways		Meiotic synapsis Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase	E3 ubiquitin ligases ubiquitinate target proteins
Drugs		Quercetin
Diseases
GWAS			Allergic rhinitis ( 30013184) Asthma ( 34103634) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma-chronic obstructive pulmonary disease overlap syndrome ( 30657218) Esophageal adenocarcinoma x smoking interaction ( 29551738) Intracranial aneurysm ( 30823506) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Manic episodes in bipolar disorder ( 26297903) Response to antipsychotic treatment ( 20195266)
Interacting Genes		12 interacting genes: APP BAG4 CDK1 EWSR1 HSPBP1 MAP3K3 MEOX2 PARP1 RNF144A SAE1 TRIM38 UBE3A	28 interacting genes: CYSLTR2 DGAT2L6 E2F1 E2F2 E2F3 E2F4 EGFR HSPA2 MFSD5 PAQR6 PARP1 RFT1 SEC22A SGTA SGTB SLC7A1 TMEM31 UBC UBE2D1 UBE2H UBE2K UBE2L3 UBE2L6 UBE2V1 UBE2V2 USP21 USP32 YIF1A
Entrez ID		3306	9781
HPRD ID		07174	11510
Ensembl ID		ENSG00000126803	ENSG00000151692
Uniprot IDs		A0A024R6B5 P54652	P50876
PDB IDs		3I33 4FSV 5FPD 5FPE 5FPM 5FPN	1WIM 6L99
Enriched GO Terms of Interacting Partners?
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