PADI4 and ANXA4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PADI4	ANXA4
Description		peptidyl arginine deiminase 4	annexin A4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Nucleus Cytoplasm Plasma Membrane Cell Surface Vesicle Membrane Cytoplasmic Vesicle Nuclear Membrane Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protein-arginine Deiminase Activity Calcium Ion Binding Protein Binding Arginine Binding Identical Protein Binding	Phospholipase Inhibitor Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Identical Protein Binding Calcium-dependent Protein Binding NF-kappaB Binding
	Biological Process	Chromatin Organization Nucleosome Assembly Chromatin Remodeling Cellular Protein Modification Process Protein Citrullination Stem Cell Population Maintenance Histone H3-R26 Citrullination Histone Citrullination Innate Immune Response	Regulation Of Transcription By RNA Polymerase II Signal Transduction Notch Signaling Pathway Epithelial Cell Differentiation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-8 Production Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity
Pathways		Chromatin modifying enzymes
Drugs		Citrulline Azithromycin Tetracycline Streptomycin N-[(1S)-1-(aminocarbonyl)-4-(ethanimidoylamino)butyl]benzamide	Fluocinolone acetonide Copper
Diseases
GWAS		Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 18849993) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) IgA nephropathy ( 32912934 25305756) Rheumatoid arthritis ( 21452313 32723749 21505073 30423114 30572963 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)	Atrial fibrillation ( 28416818 30061737) Palmitoleic acid (16:1n-7) levels ( 23362303)
Interacting Genes		13 interacting genes: ANXA4 APP FBXO25 H3C15 HDAC2 LRRK2 NPM1 OTUD3 PADI2 POU6F2 SMURF1 SZRD1 TRIB3	8 interacting genes: GP2 NMT2 PADI4 POT1 RHOU SMPD1 TINF2 UCHL5
Entrez ID		23569	307
HPRD ID		05635	00112
Ensembl ID		ENSG00000159339	ENSG00000196975
Uniprot IDs		Q9UM07	P09525 Q6LES2 Q6P452
PDB IDs		1WD8 1WD9 1WDA 2DEW 2DEX 2DEY 2DW5 3APM 3APN 3B1T 3B1U 4DKT 4X8C 4X8G 5N0M 5N0Y 5N0Z 5N1B	2ZOC
Enriched GO Terms of Interacting Partners?
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