MORC3 and RNF216

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		MORC3	RNF216
Description		MORC family CW-type zinc finger 3	ring finger protein 216
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nuclear Matrix PML Body	Nucleus Nucleoplasm Cytosol Schaffer Collateral - CA1 Synapse Postsynaptic Endocytic Zone Glutamatergic Synapse
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding Methylated Histone Binding	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Phosphorylation Cell Aging Post-embryonic Development Peptidyl-serine Phosphorylation Negative Regulation Of Fibroblast Proliferation Protein Stabilization Maintenance Of Protein Location In Nucleus	Apoptotic Process Negative Regulation Of Type I Interferon Production Regulation Of Interferon-beta Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response To Virus By Host Protein K48-linked Ubiquitination Protein Catabolic Process, Modulating Synaptic Transmission
Pathways			Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30224653) Height ( 31562340)	Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465)
Interacting Genes		12 interacting genes: ERCC6 GALNT1 HOOK3 KPNA2 RNF216 SEC61B SETD4 SUMO2 SUMO3 TBX1 UBC ZBTB32	30 interacting genes: AGFG1 BRCA1 CAPN15 FAM168A KIR2DL4 MAPK1 MORC3 OPTN RIPK1 RNF11 SUMO2 TLR3 TLR4 TLR5 TLR9 TNFAIP3 TRAF3 UBAC1 UBASH3A UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L3 UBE2L6 USP5 YOD1 ZFAND2A
Entrez ID		23515	54476
HPRD ID		10316	15550
Ensembl ID		ENSG00000159256	ENSG00000011275
Uniprot IDs		B4DHJ4 Q14149 Q4VBZ9	A8K8N1 Q9NWF9
PDB IDs		4QQ4 5SVI 5SVX 5SVY 6O1E 6O5W
Enriched GO Terms of Interacting Partners?
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