RNF216 and TLR4

  • Number of citations of the paper that reports this interaction (PubMedID 15107846)
  • 122
  • Data Source:
  • HPRD (two hybrid)

RNF216

TLR4

Description ring finger protein 216 toll like receptor 4
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465)
  • Adult body size ( 32376654)
  • Blood protein levels ( 29875488 28240269)
  • BMI (adjusted for smoking behaviour) ( 28443625)
  • BMI in non-smokers ( 28443625)
  • Body mass index ( 25673413 28448500)
  • Body mass index (joint analysis main effects and physical activity interaction) ( 28448500)
  • Body mass index (joint analysis main effects and smoking interaction) ( 28443625)
  • Body mass index in physically active individuals ( 28448500)
  • Body size at age 10 ( 32376654)
  • Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007)
  • Cognitive decline rate in late mild cognitive impairment ( 26252872)
  • Daytime nap ( 33568662)
  • Experiencing mood swings ( 29500382)
  • Feeling fed-up ( 29500382)
  • Feeling guilty ( 29500382)
  • Impulsivity (motor) ( 30718321)
  • Irritable mood ( 29500382)
  • LDL cholesterol levels in HIV infection ( 33109212)
  • Metabolite levels ( 23823483)
  • Neurociticism ( 29500382)
  • Neuroticism ( 29255261)
  • Obesity-related traits ( 23251661)
  • Osteoarthritis biomarkers ( 25057126)
  • Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311)
  • Prostate-specific antigen levels ( 28139693)
  • Triglyceride levels in HIV infection ( 33109212)
  • Voxel-wise structural brain imaging measurements in Alzheimer’s disease ( 30584014)
Interacting Genes 30 interacting genes: AGFG1 BRCA1 CAPN15 FAM168A KIR2DL4 MAPK1 MORC3 OPTN RIPK1 RNF11 SUMO2 TLR3 TLR4 TLR5 TLR9 TNFAIP3 TRAF3 UBAC1 UBASH3A UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L3 UBE2L6 USP5 YOD1 ZFAND2A 26 interacting genes: BCL10 BTK CD14 CNPY4 DEFB4A HMGB1 HSP90B1 IRAK1 IRAK2 LY96 MAPK8IP3 MYD88 NOX4 RAB14 RIPK2 RNF216 SERTAD1 SIGIRR SMAD3 SYK TICAM2 TIRAP TLR1 TLR5 TOLLIP UBQLN1
Entrez ID 54476 7099
HPRD ID 15550 04325
Ensembl ID ENSG00000011275 ENSG00000136869
Uniprot IDs A8K8N1 Q9NWF9 O00206
PDB IDs 2Z62 2Z63 2Z65 2Z66 3FXI 3UL7 3UL8 3UL9 3ULA 4G8A 5NAM 5NAO
Enriched GO Terms of Interacting Partners?
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