DAAM2 and TH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		DAAM2	TH
Description		dishevelled associated activator of morphogenesis 2	tyrosine hydroxylase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Exosome	Nucleus Cytoplasm Mitochondrion Smooth Endoplasmic Reticulum Cytosol Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Axon Dendrite Cytoplasmic Vesicle Melanosome Membrane Neuron Projection Terminal Bouton Perikaryon Perinuclear Region Of Cytoplasm
	Molecular Function	Actin Binding Small GTPase Binding	Tyrosine 3-monooxygenase Activity Protein Binding Ferrous Iron Binding Ferric Iron Binding Amino Acid Binding Oxygen Binding Enzyme Binding Protein Domain Specific Binding Tetrahydrobiopterin Binding Dopamine Binding
	Biological Process	Determination Of Left/right Symmetry Wnt Signaling Pathway Dorsal Spinal Cord Development Actin Cytoskeleton Organization Negative Regulation Of Oligodendrocyte Differentiation Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Non-canonical Wnt Signaling Pathway	Response To Hypoxia Synaptic Transmission, Dopaminergic Response To Amphetamine Heart Morphogenesis Dopamine Biosynthetic Process From Tyrosine Fatty Acid Metabolic Process Sphingolipid Metabolic Process Heart Development Visual Perception Sensory Perception Of Sound Learning Memory Mating Behavior Locomotory Behavior Regulation Of Heart Contraction Response To Water Deprivation Response To Light Stimulus Response To Herbicide Response To Salt Stress Anatomical Structure Morphogenesis Animal Organ Morphogenesis Response To Zinc Ion Multicellular Organism Aging Response To Activity Aminergic Neurotransmitter Loading Into Synaptic Vesicle Glycoside Metabolic Process Phthalate Metabolic Process Cerebral Cortex Development Response To Nutrient Levels Response To Estradiol Response To Lipopolysaccharide Isoquinoline Alkaloid Metabolic Process Social Behavior Response To Isolation Stress Response To Immobilization Stress Neurotransmitter Biosynthetic Process Terpene Metabolic Process Dopamine Biosynthetic Process Epinephrine Biosynthetic Process Norepinephrine Biosynthetic Process Eye Photoreceptor Cell Development Circadian Sleep/wake Cycle Eating Behavior Response To Peptide Hormone Pigmentation Response To Ethanol Response To Ether Response To Pyrethroid Embryonic Camera-type Eye Morphogenesis Response To Corticosterone Response To Electrical Stimulus Phytoalexin Metabolic Process Cellular Response To Manganese Ion Cellular Response To Alkaloid Cellular Response To Nicotine Cellular Response To Glucose Stimulus Cellular Response To Growth Factor Stimulus Cellular Response To Xenobiotic Stimulus Hyaloid Vascular Plexus Regression
Pathways			Catecholamine biosynthesis
Drugs			Phenylalanine Tyrosine Sapropterin Metyrosine 3-Tyrosine L-erythro-7,8-dihydrobiopterin
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Heel bone mineral density ( 30598549) Height ( 31562340) Hypospadias ( 25108383) Intraocular pressure ( 29785010) Pulmonary function ( 20010834) Subcortical volume (MOSTest) ( 32665545)	Celiac disease ( 23936387) Height ( 31562340) Hematocrit ( 32888494) Hemoglobin ( 32888494) Iron status biomarkers (ferritin levels) ( 33536631) Prostate cancer ( 19767753) Prostate cancer (early onset) ( 24740154) Prostate cancer (SNP x SNP interaction) ( 22219177) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Type 1 diabetes in high risk HLA genotype individuals (time to event) ( 29310926) Type 2 diabetes ( 31324766 25102180)
Interacting Genes		14 interacting genes: EHHADH EXOSC5 HGS KCNIP1 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 MDFI RBMY1A1 RBMY1F REL TH	32 interacting genes: CAMK2G CDK11B CRABP1 CSNK2A1 DAAM2 GAD1 HLA-G HNRNPK MAPK1 MAPK3 MAPKAPK2 MDFI NFIC NPAS1 PHLDA2 PIAS2 PRKACA PUF60 RBMY1A1 RNH1 RPS6KA5 SHC1 SNCA STIM1 TNNI2 TRIM21 TSPYL4 TYSND1 UMAD1 YWHAB YWHAZ ZNF569
Entrez ID		23500	7054
HPRD ID		09434	01865
Ensembl ID		ENSG00000146122	ENSG00000180176
Uniprot IDs		A0A0J9YYF7 Q86T65	P07101 P78428
PDB IDs			2XSN 4J6S
Enriched GO Terms of Interacting Partners?
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