TH and TSPYL4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TH	TSPYL4
Description		tyrosine hydroxylase	TSPY like 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Smooth Endoplasmic Reticulum Cytosol Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Axon Dendrite Cytoplasmic Vesicle Melanosome Membrane Neuron Projection Terminal Bouton Perikaryon Perinuclear Region Of Cytoplasm	Chromatin Nucleus
	Molecular Function	Tyrosine 3-monooxygenase Activity Protein Binding Ferrous Iron Binding Ferric Iron Binding Amino Acid Binding Oxygen Binding Enzyme Binding Protein Domain Specific Binding Tetrahydrobiopterin Binding Dopamine Binding	Chromatin Binding Protein Binding Histone Binding
	Biological Process	Response To Hypoxia Synaptic Transmission, Dopaminergic Response To Amphetamine Heart Morphogenesis Dopamine Biosynthetic Process From Tyrosine Fatty Acid Metabolic Process Sphingolipid Metabolic Process Heart Development Visual Perception Sensory Perception Of Sound Learning Memory Mating Behavior Locomotory Behavior Regulation Of Heart Contraction Response To Water Deprivation Response To Light Stimulus Response To Herbicide Response To Salt Stress Anatomical Structure Morphogenesis Animal Organ Morphogenesis Response To Zinc Ion Multicellular Organism Aging Response To Activity Aminergic Neurotransmitter Loading Into Synaptic Vesicle Glycoside Metabolic Process Phthalate Metabolic Process Cerebral Cortex Development Response To Nutrient Levels Response To Estradiol Response To Lipopolysaccharide Isoquinoline Alkaloid Metabolic Process Social Behavior Response To Isolation Stress Response To Immobilization Stress Neurotransmitter Biosynthetic Process Terpene Metabolic Process Dopamine Biosynthetic Process Epinephrine Biosynthetic Process Norepinephrine Biosynthetic Process Eye Photoreceptor Cell Development Circadian Sleep/wake Cycle Eating Behavior Response To Peptide Hormone Pigmentation Response To Ethanol Response To Ether Response To Pyrethroid Embryonic Camera-type Eye Morphogenesis Response To Corticosterone Response To Electrical Stimulus Phytoalexin Metabolic Process Cellular Response To Manganese Ion Cellular Response To Alkaloid Cellular Response To Nicotine Cellular Response To Glucose Stimulus Cellular Response To Growth Factor Stimulus Cellular Response To Xenobiotic Stimulus Hyaloid Vascular Plexus Regression	Nucleosome Assembly
Pathways		Catecholamine biosynthesis
Drugs		Phenylalanine Tyrosine Sapropterin Metyrosine 3-Tyrosine L-erythro-7,8-dihydrobiopterin
Diseases
GWAS		Celiac disease ( 23936387) Height ( 31562340) Hematocrit ( 32888494) Hemoglobin ( 32888494) Iron status biomarkers (ferritin levels) ( 33536631) Prostate cancer ( 19767753) Prostate cancer (early onset) ( 24740154) Prostate cancer (SNP x SNP interaction) ( 22219177) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Type 1 diabetes in high risk HLA genotype individuals (time to event) ( 29310926) Type 2 diabetes ( 31324766 25102180)	Fast beta electroencephalogram ( 28040410) Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042) Metabolite levels ( 23823483) Refractive error ( 32231278)
Interacting Genes		32 interacting genes: CAMK2G CDK11B CRABP1 CSNK2A1 DAAM2 GAD1 HLA-G HNRNPK MAPK1 MAPK3 MAPKAPK2 MDFI NFIC NPAS1 PHLDA2 PIAS2 PRKACA PUF60 RBMY1A1 RNH1 RPS6KA5 SHC1 SNCA STIM1 TNNI2 TRIM21 TSPYL4 TYSND1 UMAD1 YWHAB YWHAZ ZNF569	14 interacting genes: CCDC85B CDK5RAP3 CELSR3 CEP57 GOLGA6L9 MAGEA4 NAP1L3 NINL PNMA1 TFIP11 TH TRIM38 ZNF655 ZRANB1
Entrez ID		7054	23270
HPRD ID		01865	18236
Ensembl ID		ENSG00000180176	ENSG00000187189
Uniprot IDs		P07101 P78428	Q9UJ04
PDB IDs		2XSN 4J6S
Enriched GO Terms of Interacting Partners?
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