SEC61G and SFTPC

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		SEC61G	SFTPC
Description		SEC61 translocon subunit gamma	surfactant protein C
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GO Annotations	Cellular Component	Cytosol Membrane Integral Component Of Membrane Ssh1 Translocon Complex	Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Lamellar Body Clathrin-coated Endocytic Vesicle Alveolar Lamellar Body Multivesicular Body Lumen
	Molecular Function	Protein Binding Protein Transmembrane Transporter Activity	Protein Binding Identical Protein Binding
	Biological Process	Posttranslational Protein Targeting To Membrane, Translocation Protein Targeting To ER	Respiratory Gaseous Exchange By Respiratory System
Pathways		ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Surfactant metabolism Defective pro-SFTPC causes SMDP2 and RDS Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Systemic lupus erythematosus ( 24871463) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	Coronary artery disease ( 29212778) Hypertriglyceridemia ( 23505323)
Interacting Genes		10 interacting genes: AQP6 CREB3 CREB3L1 FAM209A LCN2 LRRC25 PEX12 SEC61A1 SFTPC TMEM51	36 interacting genes: BSCL2 CD200R1 CD79A CLDN5 CPLX4 CREB3 CXCL9 FAM209A FNDC9 GJA8 GOLM1 GPR152 GPX8 HPN ICAM3 IFNGR2 KLRC1 LMNA LSMEM2 MUC1 NEDD4 PDZK1IP1 PQBP1 PVR SEC22A SEC61G SIGLEC9 SMIM3 SYNE4 TMEM106C TMEM139 TMEM30B TMEM79 TMPRSS2 WWP1 WWP2
Entrez ID		23480	6440
HPRD ID		15318	01520
Ensembl ID		ENSG00000132432	ENSG00000168484
Uniprot IDs		A0A024QYZ0 P60059	A0A0A0MTC9 A0A0S2Z4Q0 E5RI64 P11686
PDB IDs		6W6L	2YAD
Enriched GO Terms of Interacting Partners?
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