ISCU and NECAB2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, two hybrid)

		ISCU	NECAB2
Description		iron-sulfur cluster assembly enzyme	N-terminal EF-hand calcium binding protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol	Cytoplasm Plasma Membrane Axon Dendrite
	Molecular Function	Iron Ion Binding Protein Binding Ferrous Iron Binding 2 Iron, 2 Sulfur Cluster Binding Molecular Adaptor Activity	Calcium Ion Binding Protein Binding A2A Adenosine Receptor Binding Type 5 Metabotropic Glutamate Receptor Binding
	Biological Process	Cellular Iron Ion Homeostasis Iron-sulfur Cluster Assembly Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Aconitate Hydratase Activity Negative Regulation Of Iron Ion Import Across Plasma Membrane	Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Adenosine Receptor Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Glutamate Receptor Signaling Pathway Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Protein Localization To Membrane
Pathways
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Intraocular pressure ( 29617998)	Body mass index (change over time) ( 25378290) Corneal astigmatism ( 29422769) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Rheumatoid arthritis ( 30891314)
Interacting Genes		18 interacting genes: AGTRAP BANP CBY2 CCDC136 CCDC172 FAM9B GOLGA2 GOLGA6L9 HPRT1 IKZF1 JUN KRT34 KRT40 LNX1 MID2 NECAB2 NUP62 PICK1	93 interacting genes: ADORA2A AIMP2 BEX2 BEX3 BYSL C19orf25 C1orf109 C1orf216 CAGE1 CAPN3 CARD9 CCDC121 CCDC146 CCDC153 CCDC33 CCNK CDC37 CENPO CPEB2 DAXX DFFA DGCR6 DGCR6L DTNBP1 DYNC1I2 EAF2 EHHADH EIF4E2 EMILIN1 FAM161A FAM161B FANCG FMR1 FXR1 FXR2 GCC1 GOLGA2 GTPBP10 HAUS1 INPP1 INTS10 ISCU KANK2 KANSL1 KDM1A KIFC3 KLC3 KLC4 KPNA2 LENG1 LNX1 MED14 MRPS27 MSGN1 MTMR9 MYO15B MYPOP NECAB1 NEK6 NIP7 NOC4L NTAQ1 ODAD3 ODAD4 OIP5 PATJ PCM1 PICK1 POLR2C PRKAA2 PRPF18 PSMA1 PUS10 RCOR3 RIC8A RUNX1T1 SDCBP SH2D4A SMARCA2 SMARCD1 SNAPIN SOGA1 SSC5D TCEA2 TEX11 TRIM59 TRIML2 TSC1 TTR USHBP1 USP7 VTA1 ZNF655
Entrez ID		23479	54550
HPRD ID		14828	13263
Ensembl ID		ENSG00000136003	ENSG00000103154
Uniprot IDs		A0A024RBI3 B1P7G3 B3KQ30 B4DNC9 Q9H1K1	Q7Z6G3
PDB IDs		5KZ5 5WKP 5WLW 6NZU 6UXE 6W1D 6WI2 6WIH
Enriched GO Terms of Interacting Partners?
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