CAPN7 and IST1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		CAPN7	IST1
Description		calpain 7	IST1 factor associated with ESCRT-III
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GO Annotations	Cellular Component	Nucleus Centrosome Cytosol Extracellular Exosome	Chromatin Extracellular Region Nuclear Envelope Endoplasmic Reticulum-Golgi Intermediate Compartment Centrosome Cytosol Midbody Azurophil Granule Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Flemming Body
	Molecular Function	Endopeptidase Activity Calcium-dependent Cysteine-type Endopeptidase Activity Protein Binding MIT Domain Binding	Protein Binding Protein Domain Specific Binding Protein-containing Complex Binding Cadherin Binding MIT Domain Binding
	Biological Process	Positive Regulation Of Epithelial Cell Migration Self Proteolysis	Protein Localization Abscission Protein Transport Viral Release From Host Cell Multivesicular Body Assembly Establishment Of Protein Localization Positive Regulation Of Proteolysis Viral Capsid Secondary Envelopment Positive Regulation Of Collateral Sprouting Cell Division Cytoskeleton-dependent Cytokinesis ESCRT III Complex Disassembly
Pathways		Degradation of the extracellular matrix	Neutrophil degranulation Sealing of the nuclear envelope (NE) by ESCRT-III
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Apolipoprotein B levels ( 32203549) Blood protein levels ( 28240269) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence (MTAG) ( 29326435) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		19 interacting genes: ARNT2 AXIN2 CEP63 CTBP2 GOLGA2 IFT88 IST1 MAD1L1 MAGED1 MDM4 PPP1R13B PRPSAP1 TNFAIP1 TRIM27 UBL7 VHL ZBTB9 ZFYVE19 ZNF655	11 interacting genes: APEH ATXN1 BAG4 CALB2 CAPN7 CHMP1A OGT SPAST TOX3 UBQLN1 UBQLN2
Entrez ID		23473	9798
HPRD ID		05908	13784
Ensembl ID		ENSG00000131375	ENSG00000182149
Uniprot IDs		Q7Z479 Q9Y6W3	B4DXC9 P53990
PDB IDs		2QFE	3FRR 3FRS 3JC1 4U7E 4U7I 4U7Y 4WZX 6E8G 6TZ4 6TZ5 6TZA
Enriched GO Terms of Interacting Partners?
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