USP22 and HEXA

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)

		USP22	HEXA
Description		ubiquitin specific peptidase 22	hexosaminidase subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	SAGA Complex Nucleoplasm	Lysosome Cytosol Membrane Azurophil Granule Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Transcription Coactivator Activity Thiol-dependent Deubiquitinase Protein Binding Zinc Ion Binding H4 Histone Acetyltransferase Activity Enzyme Binding Nuclear Receptor Coactivator Activity	Beta-N-acetylhexosaminidase Activity Protein Binding Acetylglucosaminyltransferase Activity Protein Heterodimerization Activity N-acetyl-beta-D-galactosaminidase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Embryo Development Ending In Birth Or Egg Hatching Histone Ubiquitination Histone Deubiquitination Protein Deubiquitination Histone H4 Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle	Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Ganglioside Catabolic Process Glycosaminoglycan Metabolic Process
Pathways		HATs acetylate histones Ub-specific processing proteases	Glycosphingolipid metabolism Keratan sulfate degradation CS/DS degradation Hyaluronan uptake and degradation Defective HEXA causes GM2G1
Drugs
Diseases
GWAS		Body mass index ( 26426971) Mosquito bite size ( 28199695)
Interacting Genes		17 interacting genes: AASDHPPT ATXN7 ATXN7L3 B9D1 BAG4 H2AC20 H2BC21 HEXA MRPL10 MRPL44 MTUS2 PSME1 PTGS2 RCAN1 SCFD1 SIRT1 UBC	3 interacting genes: CREBBP GM2A USP22
Entrez ID		23326	3073
HPRD ID		19411	06040
Ensembl ID		ENSG00000124422	ENSG00000213614
Uniprot IDs		Q9UPT9	A0A0S2Z3W3 B4DVA7 H3BP20 P06865
PDB IDs			1QBC 2GJX 2GK1
Enriched GO Terms of Interacting Partners?
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