SEPTIN8 and SH3GL3

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		SEPTIN8	SH3GL3
Description		septin 8	SH3 domain containing GRB2 like 3, endophilin A3
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GO Annotations	Cellular Component	Septin Ring Microtubule Cytoskeleton Axon Synaptic Vesicle Membrane Septin Complex Cell Division Site Presynapse	Acrosomal Vesicle Early Endosome Membrane Presynapse Postsynaptic Endosome Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	GTPase Activity Protein Binding GTP Binding Molecular Adaptor Activity	Protein Binding Protein C-terminus Binding Lipid Binding Identical Protein Binding
	Biological Process	Cellular Protein Localization Regulation Of SNARE Complex Assembly Cytoskeleton-dependent Cytokinesis	Endocytosis Signal Transduction Central Nervous System Development Positive Regulation Of Neuron Differentiation Negative Regulation Of Clathrin-dependent Endocytosis
Pathways			EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell NGF-stimulated transcription
Drugs
Diseases
GWAS			Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body shape index ( 34021172) Estimated glomerular filtration rate after 5 years in renal transplantation (recipient effect) ( 30920136) FEV1 ( 30804560) Gynecologic disease (multivariate analysis) ( 31488892) Height ( 28552196 25282103 18391950 18391951 20397748) Hip circumference adjusted for BMI ( 28552196 34021172) Hip index ( 34021172) Lung function (FEV1/FVC) ( 28166213 30804560) Proteinuria and chronic kidney disease ( 26420894) Smoking initiation ( 33082346) Spine bone size ( 31053729) Waist circumference adjusted for body mass index ( 34021172) Working memory ( 31598132)
Interacting Genes		12 interacting genes: A2M ACSL6 CDK14 ESR1 JADE1 KMT2B PPHLN1 SEPTIN4 SEPTIN5 SH3GL1 SH3GL3 SPTBN1	52 interacting genes: ADRB1 ANTKMT ARHGDIA ARHGEF6 ATXN2 C11orf68 C4orf17 CALCOCO1 CBLC CD101 CRIP1 DNAJC5 DNM1 DPPA4 DPYSL4 EGFL6 EGFR EMD FASLG FBXO32 GABBR2 GOLT1B HTT LRRK2 NDUFB9 PDCD6IP PIAS4 PTPRO QTRT1 RABAC1 RBM48 RER1 RNF8 RPL35A SEPTIN8 SH3D19 SH3GL1 SH3GL2 SH3KBP1 SHANK3 SHC3 SNRPN SNX24 SYNJ1 TERF1 TLE5 TMEM120B TNNT1 TOE1 VIM WASL WDR33
Entrez ID		23176	6457
HPRD ID		12228	04528
Ensembl ID		ENSG00000164402	ENSG00000140600
Uniprot IDs		A6NFQ9 B7ZVZ1 Q92599	A0A024R215 Q99963
PDB IDs		6UPR	2EW3 2Z0V
Enriched GO Terms of Interacting Partners?
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