TNIK and HARS1

Number of citations of the paper that reports this interaction (PubMedID 17043677)
193

Data Source:
BioGRID (two hybrid)

		TNIK	HARS1
Description		TRAF2 and NCK interacting kinase	histidyl-tRNA synthetase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Apical Plasma Membrane Recycling Endosome Extracellular Exosome Presynapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	Histidine-tRNA Ligase Activity ATP Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	MAPK Cascade Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Cytoskeleton Organization Wnt Signaling Pathway Microvillus Assembly Actin Cytoskeleton Reorganization Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation Neuron Projection Morphogenesis Regulation Of Dendrite Morphogenesis Protein Localization To Plasma Membrane	Translation TRNA Aminoacylation For Protein Translation Histidyl-tRNA Aminoacylation Mitochondrial Translation
Pathways		Oxidative Stress Induced Senescence	Cytosolic tRNA aminoacylation
Drugs		Fostamatinib	Histidine
Diseases
GWAS		Adolescent idiopathic scoliosis ( 28334814) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cerebrospinal fluid AB1-42 levels ( 29274321) Change in serum metabolite levels ( 31636271) Change in serum metabolite levels (CMS) ( 31636271) Cortical surface area (MOSTest) ( 32665545) Estimated glomerular filtration rate after 1 year in renal transplantation (recipient effect) ( 30920136) Frontotemporal dementia (age at onset) ( 29724592) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference adjusted for BMI ( 28552196) LDL cholesterol ( 21347282) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Night sleep phenotypes ( 27126917) Response to antipsychotic treatment in schizophrenia ( 29503163) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32154731) Type 2 diabetes ( 30054458)
Interacting Genes		37 interacting genes: ACTG1 AGTPBP1 AKAP9 ANK2 CLU CNKSR2 DPYSL2 DPYSL3 DST DYNC1H1 GOLGA4 GSE1 GSN HARS1 MACF1 NCK1 NCOR2 NEDD4 NEFM PAFAH1B1 PDE4DIP PPM1E PPP1R13B RAP2A SMARCE1 SMURF1 SNX6 SOS1 SPTBN1 SRGAP3 SYNE1 TIAM2 TNKS TRAF2 TRIM2 TUBB2A WWC1	8 interacting genes: EEF1B2 EEF1G MTNR1B OGT PSMC5 RPL5 TARS1 TNIK
Entrez ID		23043	3035
HPRD ID		18206	00827
Ensembl ID		ENSG00000154310	ENSG00000170445
Uniprot IDs		Q9UKE5	B4DDD8 B4E1C5 P12081
PDB IDs		2X7F 5AX9 5CWZ 5D7A 6RA5 6RA7	1X59 2LW7 4G84 4G85 4PHC 4X5O 5W6M 6O76
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?