CNOT1 and NOD2

		CNOT1	NOD2
Description		CCR4-NOT transcription complex subunit 1	nucleotide binding oligomerization domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	P-body Extracellular Space Nucleus Cytosol Membrane CCR4-NOT Complex CCR4-NOT Core Complex	Cytoplasm Mitochondrion Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Cell Surface Basolateral Plasma Membrane Vesicle Protein-containing Complex Phagocytic Vesicle Anchored Component Of Plasma Membrane
	Molecular Function	RNA Binding Poly(A)-specific Ribonuclease Activity Protein Binding Protein Domain Specific Binding Estrogen Receptor Binding Retinoic Acid Receptor Binding Molecular Adaptor Activity Armadillo Repeat Domain Binding	Actin Binding Protein Binding ATP Binding Enzyme Binding Protein Kinase Binding Hsp70 Protein Binding Muramyl Dipeptide Binding Pattern Recognition Receptor Activity Peptidoglycan Binding Protein-containing Complex Binding CARD Domain Binding Hsp90 Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Trophectodermal Cell Differentiation Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Negative Regulation Of Translation Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Gene Silencing By MiRNA Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Stem Cell Population Maintenance	Pattern Recognition Receptor Signaling Pathway Innate Immune Response In Mucosa Activation Of Immune Response Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Negative Regulation Of T Cell Mediated Immunity Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Dendritic Cell Cytokine Production Positive Regulation Of Type 2 Immune Response Negative Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Defense Response Positive Regulation Of Biosynthetic Process Of Antibacterial Peptides Active Against Gram-positive Bacteria Response To Nutrient Detection Of Biotic Stimulus Detection Of Bacterium Maintenance Of Gastrointestinal Epithelium Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Muramyl Dipeptide Detection Of Muramyl Dipeptide Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-18 Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Intracellular Signal Transduction Defense Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Positive Regulation Of MAP Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Gamma-delta T Cell Activation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Positive Regulation Of B Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Oxidoreductase Activity Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity Positive Regulation Of ERK1 And ERK2 Cascade Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Peptidoglycan Cellular Response To Muramyl Dipeptide Cellular Response To Organic Cyclic Compound Positive Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Neutrophil Chemotaxis Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Xenophagy Negative Regulation Of Macrophage Apoptotic Process Positive Regulation Of Prostaglandin-E Synthase Activity
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	NOD1/2 Signaling Pathway NOD1/2 Signaling Pathway TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Ovarian tumor domain proteases Interleukin-1 signaling
Drugs			Mifamurtide
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) HDL cholesterol levels ( 32203549) HDL cholesterol levels in HIV infection ( 33109212) Liver enzyme levels (alanine transaminase) ( 33972514) Oily fish consumption ( 32066663) Platelet count ( 32888494) Pork consumption ( 32066663) PR interval ( 32439900) Pulse pressure ( 30224653) QT interval ( 30679814 24952745 22726844 19305408 29874175) Schizophrenia ( 25056061 29483656 30285260) Serum alkaline phosphatase levels ( 33547301)	Asthma ( 31361310 30929738 32296059) Asthma (childhood onset) ( 31036433 30929738) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 28067908 20570966 22936669 22412388 17554300 21102463 23128233 17804789) Inflammatory bowel disease ( 18758464 28067908) Leprosy ( 20018961 27976721 25642632) Medication use (thyroid preparations) ( 31015401) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pediatric autoimmune diseases ( 26301688)
Interacting Genes		15 interacting genes: AMFR BBS2 CDC42 CNOT2 CNOT3 CNOT4 CNOT8 DDX6 HSF4 NANOS3 NOD2 PPARG RARA RXRA THRB	40 interacting genes: ALPI ANKHD1 ANXA2 ATG16L1 C10orf67 CCL13 CHMP4B CHMP5 CNOT1 DCTN1 DOCK7 ENTR1 ERBIN GOLGA6L5P GOLGB1 HAP1 IKBIP IRGM LDOC1 LMNA LURAP1L MAP3K7 NLRC4 PDLIM5 PPP1R12C PPP2R3B PRR16 RIPK2 RPL13A SCYL1 SETD6 TACC3 TNIP1 TPM1 TPM3 TPM4 TRIM41 VCP WBP11 XIAP
Entrez ID		23019	64127
HPRD ID		11999	05810
Ensembl ID		ENSG00000125107	ENSG00000167207
Uniprot IDs		A5YKK6	A0A286YF65 Q9HC29
PDB IDs		4C0D 4CQO 4CRU 4CRV 4CRW 4CT4 4CT6 4CT7 4GMJ 4GML 4J8S 5ANR 5FU6 5FU7 5ONA
Enriched GO Terms of Interacting Partners?
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