CNOT1 and AMFR

		CNOT1	AMFR
Description		CCR4-NOT transcription complex subunit 1	autocrine motility factor receptor
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GO Annotations	Cellular Component	P-body Extracellular Space Nucleus Cytosol Membrane CCR4-NOT Complex CCR4-NOT Core Complex	Ubiquitin Ligase Complex Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Dendrite Growth Cone Protein-containing Complex Derlin-1 Retrotranslocation Complex Neuronal Cell Body Endoplasmic Reticulum Quality Control Compartment Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Poly(A)-specific Ribonuclease Activity Protein Binding Protein Domain Specific Binding Estrogen Receptor Binding Retinoic Acid Receptor Binding Molecular Adaptor Activity Armadillo Repeat Domain Binding	Ubiquitin-protein Transferase Activity Protein Binding Protein-macromolecule Adaptor Activity Ubiquitin-ubiquitin Ligase Activity Signaling Receptor Activity Identical Protein Binding Ubiquitin Binding Metal Ion Binding Chaperone Binding Ubiquitin Protein Ligase Activity BAT3 Complex Binding Ubiquitin-specific Protease Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Trophectodermal Cell Differentiation Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Negative Regulation Of Translation Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Gene Silencing By MiRNA Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Stem Cell Population Maintenance	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Signal Transduction Aging Learning Or Memory Wnt Signaling Pathway Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Binding Protein Autoubiquitination Protein K48-linked Ubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Endoplasmic Reticulum Mannose Trimming Regulation Of SREBP Signaling Pathway
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	N-glycan trimming in the ER and Calnexin/Calreticulin cycle ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) HDL cholesterol levels ( 32203549) HDL cholesterol levels in HIV infection ( 33109212) Liver enzyme levels (alanine transaminase) ( 33972514) Oily fish consumption ( 32066663) Platelet count ( 32888494) Pork consumption ( 32066663) PR interval ( 32439900) Pulse pressure ( 30224653) QT interval ( 30679814 24952745 22726844 19305408 29874175) Schizophrenia ( 25056061 29483656 30285260) Serum alkaline phosphatase levels ( 33547301)	Apolipoprotein A1 levels ( 32203549) Breast cancer ( 29059683)
Interacting Genes		15 interacting genes: AMFR BBS2 CDC42 CNOT2 CNOT3 CNOT4 CNOT8 DDX6 HSF4 NANOS3 NOD2 PPARG RARA RXRA THRB	30 interacting genes: BAG6 CNOT1 CRMP1 CSNK2A2 CYP2E1 DERL1 DHFR GPI HERPUD1 HTT KPNB1 MGRN1 SOD1 TOM1L1 TRIM25 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2G2 UBE2K UBE2N UBE2T UBE2W UBL4A UFD1 USP13 VCP
Entrez ID		23019	267
HPRD ID		11999	09130
Ensembl ID		ENSG00000125107	ENSG00000159461
Uniprot IDs		A5YKK6	A0A024R6R5 Q9UKV5
PDB IDs		4C0D 4CQO 4CRU 4CRV 4CRW 4CT4 4CT6 4CT7 4GMJ 4GML 4J8S 5ANR 5FU6 5FU7 5ONA	2EJS 2LVN 2LVO 2LVP 2LVQ 2LXH 2LXP 3FSH 3H8K 3TIW 4G3O 4LAD
Enriched GO Terms of Interacting Partners?
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