SCMH1 and GMNN

Number of citations of the paper that reports this interaction (PubMedID 14973489)
76

Data Source:
HPRD (in vitro)

		SCMH1	GMNN
Description		Scm polycomb group protein homolog 1	geminin DNA replication inhibitor
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromocenter	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Chromatin Binding Protein Binding Histone Binding	Chromatin Binding Transcription Corepressor Activity Protein Binding Histone Deacetylase Binding DNA-binding Transcription Factor Binding
	Biological Process	Chromatin Remodeling Spermatogenesis Anterior/posterior Pattern Specification Gene Silencing Negative Regulation Of Transcription, DNA-templated	Regulation Of DNA Replication Negative Regulation Of DNA Replication Animal Organ Morphogenesis Positive Regulation Of Chromatin Binding Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated DNA Replication Preinitiation Complex Assembly Negative Regulation Of DNA-dependent DNA Replication
Pathways			CDT1 association with the CDC6:ORC:origin complex Activation of the pre-replicative complex
Drugs		Mercaptoethanol
Diseases
GWAS		Adventurousness ( 30643258) Appendicular lean mass ( 33097823) Atrial fibrillation ( 30061737 29892015) General risk tolerance (MTAG) ( 30643258) Height ( 20881960 25282103 23563607 18391952) Hip circumference adjusted for BMI ( 34021172) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Rapid response to perioperative phenylephrine (change in mean arterial pressure) ( 33168928)	Metabolite levels ( 23823483)
Interacting Genes		22 interacting genes: EWSR1 FXR1 FXR2 GMNN HK1 HPCAL4 LYPLA2 LZTR1 MAGEA12 MAML3 MOB4 PCBD1 PHC1 PHC2 POLR2M SFMBT1 SFMBT2 TMEM11 TOB1 TSC1 UBQLN1 UBQLN4	34 interacting genes: ARNT AURKA CASP3 CCDC146 CDC20 CDKN1A CDKN2A CDT1 CSNK2A1 FZR1 GLIS2 HOXA10 HOXA11 HOXA7 HOXB7 HOXC8 HOXC9 HOXD10 IMPDH1 KANK2 KAT7 LNX1 MCM6 NCF1 PHC1 PTPN11 REPIN1 SAPCD2 SCMH1 SHANK2 SIX3 SMARCA4 ZNF250 ZNF439
Entrez ID		22955	51053
HPRD ID		11540	06783
Ensembl ID		ENSG00000010803	ENSG00000112312
Uniprot IDs		B3KMZ7 Q96GD3	A0A024QZY7 O75496
PDB IDs		2P0K	1T6F 1UII 2LP0 2WVR 4BRY
Enriched GO Terms of Interacting Partners?
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