MSRB2 and CACNB2

		MSRB2	CACNB2
Description		methionine sulfoxide reductase B2	calcium voltage-gated channel auxiliary subunit beta 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Calcium Channel Complex Photoreceptor Ribbon Synapse Presynapse L-type Voltage-gated Calcium Channel Complex
	Molecular Function	Actin Binding Protein Binding Zinc Ion Binding Peptide-methionine (R)-S-oxide Reductase Activity L-methionine-(R)-S-oxide Reductase Activity	Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Actin Filament Binding Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential Voltage-gated Calcium Channel Activity Involved In AV Node Cell Action Potential Voltage-gated Calcium Channel Activity Involved In Positive Regulation Of Presynaptic Cytosolic Calcium Levels
	Biological Process	Response To Oxidative Stress Actin Filament Polymerization Protein Repair	Chemical Synaptic Transmission Neuromuscular Junction Development Visual Perception Positive Regulation Of Calcium Ion Transport Calcium Ion Import Calcium Ion Transmembrane Transport Protein Localization To Plasma Membrane Membrane Depolarization During AV Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential Induction Of Synaptic Vesicle Exocytosis By Positive Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of High Voltage-gated Calcium Channel Activity Positive Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel
Pathways		Protein repair	Presynaptic depolarization and calcium channel opening Adrenaline,noradrenaline inhibits insulin secretion NCAM1 interactions Regulation of insulin secretion Regulation of insulin secretion Phase 0 - rapid depolarisation Phase 2 - plateau phase Sensory processing of sound by inner hair cells of the cochlea
Drugs			Ergocalciferol Enflurane Ranolazine Phenytoin Isradipine Topiramate Nimodipine Nisoldipine Spironolactone Nicardipine Magnesium sulfate Levomenthol Felodipine Nitrendipine Miconazole Nifedipine Amiodarone Mibefradil Dronedarone Nilvadipine Trimebutine Benidipine Cilnidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132) Obesity-related traits ( 23251661)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Antisaccade task score ( 31596458) Apolipoprotein B levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood pressure ( 21909110) Body mass index ( 28892062) Brain volume in infants (grey matter) ( 28763065) Cadmium levels ( 26025379) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diastolic blood pressure ( 19430479 27841878 21909115 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diverticular disease ( 30177863) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hypertension ( 31879980 19430479 21909115) LDL cholesterol levels ( 32203549) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Metabolite levels (HVA/MHPG ratio) ( 23319000) Nicotine dependence symptom count ( 25555482) Obesity-related traits ( 23251661) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328) Protein quantitative trait loci ( 18464913) Pulse pressure ( 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Quantitative traits ( 19197348) Response to antiepileptic drugs in genetic generalized epilepsy ( 32308125) Schizophrenia ( 28991256 25056061 29483656 30285260 23974872) Small vessel stroke ( 26732560) Systolic blood pressure ( 28135244 19430479 27841878 21909115 28739976 27618452 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) White matter hyperintensity volume ( 33293549)
Interacting Genes		5 interacting genes: CACNB2 NRP1 RAD21 TRAF2 ZDHHC17	13 interacting genes: C10orf67 CTBP2 GPR85 HEXIM2 MSRB2 NEBL NRP1 PDIA3 PRKACA PRMT5 PTER REM1 TMEM174
Entrez ID		22921	783
HPRD ID		17606	02473
Ensembl ID		ENSG00000148450	ENSG00000165995
Uniprot IDs		Q9Y3D2	A0A494C0B2 A0A494C184 Q08289 Q59H42 Q5VVH1
PDB IDs
Enriched GO Terms of Interacting Partners?
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