SACM1L and FMO3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SACM1L	FMO3
Description		SAC1 like phosphatidylinositide phosphatase	flavin containing dimethylaniline monoxygenase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Integral Component Of Endoplasmic Reticulum Membrane Endoplasmic Reticulum-plasma Membrane Contact Site	Endoplasmic Reticulum Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Phosphatidylinositol-3-phosphatase Activity Protein Binding Phosphatase Activity Phosphatidylinositol Bisphosphate Phosphatase Activity Phosphatidylinositol Phosphate 4-phosphatase Activity Phosphatidylinositol-4-phosphate Phosphatase Activity	Monooxygenase Activity N,N-dimethylaniline Monooxygenase Activity Protein Binding Trimethylamine Monooxygenase Activity Flavin Adenine Dinucleotide Binding NADP Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Phosphatidylinositol Dephosphorylation
Pathways		Synthesis of PIPs at the ER membrane Synthesis of PIPs at the Golgi membrane	FMO oxidises nucleophiles Defective FMO3 causes TMAU
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Macular telangiectasia type 2 ( 33654266) Response to anti-depressant treatment in major depressive disorder ( 22041458) Serum metabolite levels ( 33031748) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Blood metabolite levels ( 24816252) Lentiform nucleus volume ( 22903471) Serum metabolite levels ( 33031748)
Interacting Genes		35 interacting genes: ACKR2 AQP6 ARL13B CD79A COPA COPB2 COPG1 CREB3 CREB3L1 DHRS7 EBP FFAR2 FMO3 GPR151 GPR152 HSD17B13 JAGN1 LMNA MFF MFSD14B MTERF2 ODF4 PRKCA RNF19B RTN3 SCN3B SLC10A1 SLC10A6 SLC35A5 SLC35C2 SLC7A1 TMEM167B TMX2 VEZT ZFYVE27	5 interacting genes: CLEC10A CREB3 SACM1L SERPINC1 SGSM3
Entrez ID		22908	2328
HPRD ID		07587	00633
Ensembl ID		ENSG00000211456	ENSG00000007933
Uniprot IDs		B4DVV3 E9PGZ4 Q9NTJ5	A0A024R8Z4 B7Z3M2 B7Z543 P31513 Q53FW5
PDB IDs
Enriched GO Terms of Interacting Partners?
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