MRAS and RAPGEF5

Number of citations of the paper that reports this interaction (PubMedID 10934204)
43

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		MRAS	RAPGEF5
Description		muscle RAS oncogene homolog	Rap guanine nucleotide exchange factor 5
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane	Nucleus Nucleoplasm Nuclear Body
	Molecular Function	GTPase Activity G Protein Activity Protein Binding GTP Binding GDP Binding GTP-dependent Protein Binding	Guanyl-nucleotide Exchange Factor Activity GTP-dependent Protein Binding
	Biological Process	Ras Protein Signal Transduction Multicellular Organism Development Muscle Organ Development Actin Cytoskeleton Organization Cellular Response To Leukemia Inhibitory Factor	Small GTPase Mediated Signal Transduction Nervous System Development Regulation Of Catalytic Activity
Pathways		RAF activation SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blond vs. brown/black hair color ( 30531825) Body mass index ( 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body shape index ( 34021172) Body size at age 10 ( 32376654) Chronotype ( 30696823) Coronary artery disease ( 32469254 29212778 24262325 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 19198612 21378990) Daytime nap ( 33568662) Diastolic blood pressure ( 27841878) Essential hypertension (time to event) ( 32589924) Myocardial infarction ( 33532862) Systolic blood pressure ( 27841878) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Asthma ( 34103634) Cutaneous malignant melanoma ( 32341527) Depression in smokers ( 30219690) Dialysis-related mortality ( 21546767) Diastolic blood pressure ( 30224653) Gamma glutamyl transferase levels ( 33339817) Glaucoma ( 30104761) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Night sleep phenotypes ( 27126917) Spatial processing ( 31596458) Squamous cell lung carcinoma ( 28604730) Thyroid stimulating hormone levels ( 17903292) Urinary albumin excretion ( 32277301)
Interacting Genes		11 interacting genes: AFDN BRAF ELOC PIK3CA RAF1 RALGDS RAPGEF5 RAPGEF6 RASIP1 RASSF5 RHOU	8 interacting genes: ITGB8 MRAS PLAC9 RAP1A RAP2A RAP2B TMEM253 VANGL1
Entrez ID		22808	9771
HPRD ID		06662	15208
Ensembl ID		ENSG00000158186	ENSG00000136237
Uniprot IDs		O14807 Q6FGP0 Q8WVM9	A8MQ07 Q5JPD2 Q92565
PDB IDs			1WGY
Enriched GO Terms of Interacting Partners?
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