MRAS and RASSF5

Number of citations of the paper that reports this interaction (PubMedID 11857081)
66

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		MRAS	RASSF5
Description		muscle RAS oncogene homolog	Ras association domain family member 5
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane	Nucleus Cytoplasm Microtubule
	Molecular Function	GTPase Activity G Protein Activity Protein Binding GTP Binding GDP Binding GTP-dependent Protein Binding	Protein Binding Small GTPase Binding Metal Ion Binding
	Biological Process	Ras Protein Signal Transduction Multicellular Organism Development Muscle Organ Development Actin Cytoskeleton Organization Cellular Response To Leukemia Inhibitory Factor	Apoptotic Process Signal Transduction Negative Regulation Of Cell Population Proliferation Positive Regulation Of Protein Ubiquitination Intracellular Signal Transduction Regulation Of Apoptotic Process Regulation Of Protein Localization To Nucleus
Pathways		RAF activation SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blond vs. brown/black hair color ( 30531825) Body mass index ( 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body shape index ( 34021172) Body size at age 10 ( 32376654) Chronotype ( 30696823) Coronary artery disease ( 32469254 29212778 24262325 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 19198612 21378990) Daytime nap ( 33568662) Diastolic blood pressure ( 27841878) Essential hypertension (time to event) ( 32589924) Myocardial infarction ( 33532862) Systolic blood pressure ( 27841878) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Inflammatory bowel disease ( 23128233) Late-onset Alzheimer's disease ( 27770636) Neurofibrillary tangles ( 25188341)
Interacting Genes		11 interacting genes: AFDN BRAF ELOC PIK3CA RAF1 RALGDS RAPGEF5 RAPGEF6 RASIP1 RASSF5 RHOU	30 interacting genes: ADH6 AMOTL2 APPBP2 BTRC HRAS KRAS KRT40 KRTAP4-2 LSM7 MRAS MYLIP NRAS RABIF RALA RAP1B RAP2A RAP2B RASSF1 RASSF2 REL RRAS RRAS2 SMAD4 STK4 TERF2IP TRAF1 TRAF2 UBQLN1 UBQLN2 VPS28
Entrez ID		22808	83593
HPRD ID		06662	06117
Ensembl ID		ENSG00000158186	ENSG00000266094
Uniprot IDs		O14807 Q6FGP0 Q8WVM9	A8K5F3 Q8WWW0
PDB IDs			4LGD 4OH8
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?