FGR and SLAMF1

Number of citations of the paper that reports this interaction (PubMedID 10229804)
16

Data Source:
HPRD (in vivo, in vitro)

		FGR	SLAMF1
Description		FGR proto-oncogene, Src family tyrosine kinase	signaling lymphocytic activation molecule family member 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Aggresome Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ruffle Membrane Secretory Granule Lumen Extracellular Exosome	External Side Of Plasma Membrane Integral Component Of Membrane Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Phosphotyrosine Residue Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Protein Kinase Binding Immunoglobulin Receptor Binding Fc-gamma Receptor I Complex Binding	Virus Receptor Activity Antigen Binding Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity SH2 Domain Binding Identical Protein Binding
	Biological Process	Positive Regulation Of Cytokine Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Cell Shape Response To Virus Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cell Differentiation Bone Mineralization Positive Regulation Of Cell Migration Negative Regulation Of Natural Killer Cell Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Mast Cell Degranulation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Regulation Of Innate Immune Response Regulation Of Protein Kinase Activity Protein Autophosphorylation Skeletal System Morphogenesis Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium	Natural Killer Cell Differentiation Natural Killer Cell Proliferation Leukocyte Chemotaxis Involved In Inflammatory Response Adaptive Immune Response Myeloid Dendritic Cell Activation Involved In Immune Response Negative Regulation Of T Cell Cytokine Production Phagocytosis Cell Adhesion Positive Regulation Of Cell Population Proliferation Positive Regulation Of Macrophage Chemotaxis Regulation Of Vesicle Fusion Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Activated T Cell Proliferation Innate Immune Response Positive Regulation Of JNK Cascade Viral Entry Into Host Cell Regulation Of Catalytic Activity Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of CD40 Signaling Pathway Positive Regulation Of Dendritic Cell Chemotaxis Positive Regulation Of T-helper 1 Cell Cytokine Production
Pathways		FCGR activation Platelet sensitization by LDL Neutrophil degranulation FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis
Drugs		Dasatinib Fostamatinib Zanubrutinib
Diseases
GWAS		Body mass index ( 28892062) Systolic blood pressure ( 30224653)	Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Memory decline ( 31985465) Microalbuminuria ( 26631737) Multiple sclerosis ( 31604244) Schizophrenia (treatment resistant) ( 22479419)
Interacting Genes		30 interacting genes: AR ARRB1 CBL CCR3 CSK DAB2 DOK1 EGFR ERBB2 ERBB3 ERBB4 FASLG HCLS1 IKBKG INPP5D KHDRBS1 KIT MET NR1I2 PTK2 SKAP2 SLAMF1 SMURF1 SNCA SRC STAT3 SYK VDR WAS YWHAQ	7 interacting genes: FGR FYN INPP5D PAX6 PTPN11 SH2D1A SH2D1B
Entrez ID		2268	6504
HPRD ID		01288	04603
Ensembl ID		ENSG00000000938	ENSG00000117090
Uniprot IDs		P09769 P78453	Q13291
PDB IDs			1D4T 1D4W 1I3Z 1KA6 1KA7 1M27 2DZF 2IE9 2IFL 2IG5
Enriched GO Terms of Interacting Partners?
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