FGF12 and ZNF460

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		FGF12	ZNF460
Description		fibroblast growth factor 12	zinc finger protein 460
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Synapse	Nucleus
	Molecular Function	Protein Binding Growth Factor Activity Sodium Channel Regulator Activity Transmembrane Transporter Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Membrane Depolarization Signal Transduction Cell-cell Signaling Chemical Synaptic Transmission Nervous System Development Heart Development Adult Locomotory Behavior Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Sodium Ion Transport Neuromuscular Process Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Neuronal Action Potential Regulation Of Sodium Ion Transmembrane Transport Regulation Of Voltage-gated Sodium Channel Activity Regulation Of Sodium Ion Transmembrane Transporter Activity Negative Regulation Of Cation Channel Activity	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II
Pathways		Phase 0 - rapid depolarisation	Generic Transcription Pathway
Drugs
Diseases
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Bipolar disorder ( 31043756) Fasting glucose ( 34059833) Gut microbiota relative abundance (Ruminococcus belonging to family Erysipelotrichaceae) ( 33208821) HDL cholesterol levels in HIV infection ( 33109212) Height ( 32902719) Hip circumference adjusted for BMI ( 28552196) Idiopathic dilated cardiomyopathy ( 29495422) Ileal carcinoids ( 21139019) Major depressive disorder ( 23377640) Metabolite levels ( 19043545) Orofacial cleft x maternal periconceptional smoking interaction (1df) ( 33937227) Post bronchodilator FEV1/FVC ratio ( 26634245) PR interval ( 32439900) Serum metabolite concentrations in chronic kidney disease ( 29545352) Severe influenza A (H1N1) infection ( 26379185) Sleep quality ( 23728906)	Heel bone mineral density ( 30598549)
Interacting Genes		27 interacting genes: AP2M1 APP COIL CT45A1 DACH1 DCTD DPPA2 GRIP1 IKZF1 IL2RA LZTS2 MAPK13 MAPK8IP2 NEDD4 NEDD4L PJA1 RBAK RNF151 RP9 SMURF1 SRPK1 SRPK2 STAC3 THAP1 YWHAE ZNF460 ZNF79	10 interacting genes: DEUP1 FGF12 LMO1 MTNR1A OGT TRIM41 TRIM55 TRIM63 ZNF250 ZNF330
Entrez ID		2257	10794
HPRD ID		03303	06885
Ensembl ID		ENSG00000114279	ENSG00000197714
Uniprot IDs		P61328	Q14592
PDB IDs		1Q1U 4JQ0
Enriched GO Terms of Interacting Partners?
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