ADGRF5 and SEC13

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ADGRF5	SEC13
Description		adhesion G protein-coupled receptor F5	SEC13 homolog, nuclear pore and COPII coat complex component
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Integral Component Of Membrane Cytoplasmic Vesicle Apical Part Of Cell	Kinetochore Nuclear Envelope Nucleoplasm Lysosomal Membrane Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane COPII Vesicle Coat Nuclear Pore Outer Ring Intracellular Membrane-bounded Organelle GATOR2 Complex Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding	Structural Molecule Activity Protein Binding Identical Protein Binding
	Biological Process	Glomerular Filtration Energy Reserve Metabolic Process Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Glucose Homeostasis Negative Regulation Of Macrophage Activation Surfactant Homeostasis Fat Cell Differentiation Erythrocyte Development Pharyngeal Arch Artery Morphogenesis Positive Regulation Of Phospholipid Biosynthetic Process	Protein Import Into Nucleus Intracellular Protein Transport Positive Regulation Of TOR Signaling Protein Exit From Endoplasmic Reticulum MRNA Transport COPII-coated Vesicle Cargo Loading COPII-coated Vesicle Budding Positive Regulation Of TORC1 Signaling
Pathways		Surfactant metabolism	ISG15 antiviral mechanism Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly COPII-mediated vesicle transport MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) RHO GTPases Activate Formins tRNA processing in the nucleus Mitotic Prometaphase HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation Amino acids regulate mTORC1 EML4 and NUDC in mitotic spindle formation Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Waist-hip ratio ( 28552196)	Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		4 interacting genes: CABP2 FNDC3B NFYC SEC13	14 interacting genes: ADGRF5 CFAP43 CLDN12 EGFR HAPLN2 HSPB1 LTB4R2 NUP98 OXNAD1 RAB11A SEC16B SEC31A TRAF5 WDR44
Entrez ID		221395	6396
HPRD ID		11010	02538
Ensembl ID		ENSG00000069122	ENSG00000157020
Uniprot IDs		Q8IZF2	A8MWR8 P55735
PDB IDs			3BG0 3BG1 5A9Q
Enriched GO Terms of Interacting Partners?
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