FCER1A and MS4A2

Number of citations of the paper that reports this interaction (PubMedID 1535625)
11

Data Source:
HPRD (in vivo)

		FCER1A	MS4A2
Description		Fc fragment of IgE receptor Ia	membrane spanning 4-domains A2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface	Plasma Membrane Integral Component Of Plasma Membrane Fc-epsilon Receptor I Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding IgE Binding	Protein Binding IgE Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Regulation Of Immune Response	Inflammatory Response Immune Response Fc-epsilon Receptor Signaling Pathway
Pathways		Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization FCERI mediated NF-kB activation	Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization FCERI mediated NF-kB activation
Drugs		Omalizumab Benzylpenicilloyl polylysine TNX-901	Omalizumab
Diseases
GWAS		C-reactive protein ( 22939635) IgE levels ( 18846228 22075330) Obesity-related traits ( 23251661) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Select biomarker traits ( 17903293) White blood cell count ( 27863252)	Alzheimer's disease ( 31473137)
Interacting Genes		7 interacting genes: FCER1G FCGR2A ITIH2 LMNA MESD MS4A2 PDHB	11 interacting genes: AKT1 APP FCER1A GRB2 HSP90AA1 LYN PRKCD PTPN11 PTPN6 SYK TMEM86A
Entrez ID		2205	2206
HPRD ID		00917	00915
Ensembl ID		ENSG00000179639	ENSG00000149534
Uniprot IDs		P12319	A0A0B4J2E9 Q01362
PDB IDs		1ALS 1ALT 1F2Q 1F6A 1J86 1J87 1J88 1J89 1RPQ 2Y7Q
Enriched GO Terms of Interacting Partners?
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