MARK2 and PLAAT3

		MARK2	PLAAT3
Description		microtubule affinity regulating kinase 2	phospholipase A and acyltransferase 3
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Actin Filament Plasma Membrane Membrane Lateral Plasma Membrane Dendrite Microtubule Bundle	Cellular_component Nuclear Envelope Cytoplasm Mitochondrion Lysosome Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Cytosol Plasma Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Magnesium Ion Binding RNA Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Lipid Binding Protein Kinase Activator Activity Cadherin Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity	Phospholipase A2 Activity Protein Binding Phospholipase A1 Activity N-acyltransferase Activity Acyltransferase Activity Phosphatidylserine 1-acylhydrolase Activity 1-acyl-2-lysophosphatidylserine Acylhydrolase Activity
	Biological Process	Microtubule Cytoskeleton Organization Autophagy Of Mitochondrion Neuron Migration Protein Phosphorylation Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Establishment Of Cell Polarity Activation Of Protein Kinase Activity Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Autophosphorylation Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Mitochondrion Localization Axon Development Regulation Of Microtubule Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Regulation Of Microtubule Binding	Triglyceride Metabolic Process Phospholipid Metabolic Process Peroxisome Organization Phospholipid Biosynthetic Process Response To Bacterium Lipid Catabolic Process Membrane Disassembly Phosphatidylethanolamine Acyl-chain Remodeling Negative Regulation Of Cell Cycle Ether Lipid Metabolic Process N-acylphosphatidylethanolamine Metabolic Process Lens Fiber Cell Differentiation Organelle Disassembly Regulation Of Adipose Tissue Development
Pathways			Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI
Drugs		Fostamatinib
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132)
Interacting Genes		42 interacting genes: BAIAP2 CAMK1 CASK DVL3 FBXO7 FLRT1 GAB1 GSK3B HDAC7 INCENP ISOC1 KIF13B KIFAP3 MAP3K3 MAPT MTCL1 NEDD4 NEDD4L NUAK1 NXF1 OSBP PARD3B PARD6A PINK1 PKD1 PLAAT3 PPP2R5B PRKCE PTPRD RAB11FIP2 RNF41 RPA2 RPS6KB1 SCGB1A1 SMURF1 STK11 STK3 STK4 UTRN YWHAB YWHAQ YWHAZ	5 interacting genes: MARK2 PPP2R1A UBQLN1 UBQLN2 UBQLN4
Entrez ID		2011	11145
HPRD ID		02753	13671
Ensembl ID		ENSG00000072518	ENSG00000176485
Uniprot IDs		A0A140VJP1 A8K2S4 E7ETY4 Q7KZI7	A0A024R561 P53816
PDB IDs		3IEC 5EAK 5KZ7 5KZ8	2KYT 4DOT 4FA0 4Q95
Enriched GO Terms of Interacting Partners?
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