ELK3 and APAF1

		ELK3	APAF1
Description		ETS transcription factor ELK3	apoptotic peptidase activating factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Mitochondrion	Extracellular Region Cytosol Protein-containing Complex Secretory Granule Lumen Apoptosome Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Purine-rich Negative Regulatory Element Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Heat Shock Protein Binding Identical Protein Binding ADP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Regulation Of Transcription By RNA Polymerase II Signal Transduction Cell Differentiation Wound Healing Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Response To Hypoxia Kidney Development Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Nervous System Development Brain Development Aging Response To Nutrient Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Cardiac Muscle Cell Apoptotic Process Cell Differentiation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To G1 DNA Damage Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway
Pathways			Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Neutrophil degranulation TP53 Regulates Transcription of Caspase Activators and Caspases Transcriptional Regulation by E2F6 Regulation of the apoptosome activity Regulation of the apoptosome activity
Drugs			ATP
Diseases
GWAS		Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299 27694927) B-cell acute lymphoblastic leukaemia ( 31767839) Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382) Small intestine neuroendocrine tumor ( 27492634) Thyroid stimulating hormone levels ( 32769997) Vaginal microbiome composition (community state type) ( 32723796)	Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172)
Interacting Genes		14 interacting genes: APAF1 APP BPIFA1 CRK CTBP1 ID2 MAPK14 MAPK8 MAPK9 PFDN5 PIAS1 SP4 TCF3 TOP1	30 interacting genes: ACADS APIP AVEN BCL2L1 BCL2L10 CASP3 CASP4 CASP8 CASP9 CCL13 CDK17 CYCS DZIP1 ELK3 FAS FEM1B HIP1 HNF1A HSP90AA1 HSPA1A MRPL19 NLRP1 NR1H4 NUDT4 PAH PPP1CA RPL26L1 TOP1 TRIAP1 UTP20
Entrez ID		2004	317
HPRD ID		02593	03755
Ensembl ID		ENSG00000111145	ENSG00000120868
Uniprot IDs		A0A024RBE2 P41970	O14727
PDB IDs			1C15 1CWW 1CY5 1Z6T 2P1H 2YGS 3J2T 3JBT 3YGS 4RHW 5JUY 5WVC 5WVE
Enriched GO Terms of Interacting Partners?
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