UBR1 and TP53I3

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

		UBR1	TP53I3
Description		ubiquitin protein ligase E3 component n-recognin 1	tumor protein p53 inducible protein 3
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Proteasome Complex Cytoplasm Cytosol	Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity Leucine Binding	NADPH:quinone Reductase Activity Protein Homodimerization Activity Quinone Binding NADPH Binding
	Biological Process	Protein Ubiquitination Negative Regulation Of TOR Signaling Cellular Response To Leucine Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway	NADP Metabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
Drugs
Diseases
GWAS		Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) MGMT methylation in smokers ( 26183928) Triglycerides ( 25961943)
Interacting Genes		31 interacting genes: ANXA3 ARL15 ARL3 ARL4D ATF3 BCL2L1 BTBD2 CDC42 CDC6 DLEU1 DNAJB11 FOS FTH1 GADD45A GSK3B LAMA4 LAMTOR3 NDUFA4L2 NR3C1 NTAN1 NTAQ1 NUDT3 PKNOX1 PTPRS SERPINB9 SPRY2 TAC3 TP53I3 UBE2A UBE2B UBE2D2	7 interacting genes: EEF1G FUNDC2 GPX3 MDM2 RAB10 UBR1 UNC119
Entrez ID		197131	9540
HPRD ID		09342	05527
Ensembl ID		ENSG00000159459	ENSG00000115129
Uniprot IDs		Q8IWV7	B4DMQ7 Q53FA7
PDB IDs		3NY1 5TDC	2J8Z 2OBY
Enriched GO Terms of Interacting Partners?
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