PLPP4 and CISD2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PLPP4	CISD2
Description		phospholipid phosphatase 4	CDGSH iron sulfur domain 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Protein-containing Complex Perinuclear Endoplasmic Reticulum
	Molecular Function	Diacylglycerol Diphosphate Phosphatase Activity Protein Binding Phosphatidate Phosphatase Activity Lipid Phosphatase Activity Identical Protein Binding	RNA Binding Protein Binding Protein Homodimerization Activity Metal Ion Binding 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Blastocyst Hatching Phospholipid Metabolic Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Phospholipid Dephosphorylation Regulation Of Calcium Ion Import	Autophagy Of Mitochondrion Multicellular Organism Aging Regulation Of Autophagy
Pathways		Role of phospholipids in phagocytosis
Drugs
Diseases
GWAS		Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)	Asthma and attention deficit hyperactivity disorder ( 31619474) Estimated glomerular filtration rate ( 31152163) Primary biliary cholangitis ( 26394269) Schizophrenia ( 28991256) Type 2 diabetes ( 28869590)
Interacting Genes		33 interacting genes: ANKRD46 ARL13B BCL2L13 BIK BMP10 CD74 CISD2 CPLX4 CREB3L1 CYB5B ERGIC3 EVI2A FAM209A FRMD3 GET1 GJA1 GJB5 GPX8 LMNA LRRC59 MGST3 PAGE1 PDZK1IP1 PSCA SGPL1 SLC35A1 SSMEM1 STX1A STX2 SYT2 TMEM139 TMEM45B UPK1B	58 interacting genes: AIG1 APOL2 APP AQP10 BCL2L2 BET1 BMP10 BTN2A2 C14orf180 C2CD2L C4orf3 CDIPT CFHR5 CLDN10 CLN6 CYBC1 EHHADH EMD FAM241B GALNT15 GAST GPR37L1 HHATL IER3 KIR2DL3 LEPROTL1 LRP10 MAN2B2 MIP NAPB NRG4 NSG1 PGAP2 PLPP4 PLPPR2 PNKP POMGNT1 RTP2 RUSF1 SEC22A SERP2 SLC13A3 SLC35B4 SMIM1 SNORC SPP1 STX12 STX7 THSD7B TMEM187 TMEM243 TMEM43 TMEM86A TSPAN33 TTPA VAMP4 VKORC1L1 YIPF6
Entrez ID		196051	493856
HPRD ID		18745	17413
Ensembl ID		ENSG00000203805	ENSG00000145354
Uniprot IDs		B7Z3R3 Q5VZY2	Q8N5K1
PDB IDs			3FNV 4OO7 4OOA
Enriched GO Terms of Interacting Partners?
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