DSC2 and DSG2

Number of citations of the paper that reports this interaction (PubMedID 11853539)
42

Data Source:
HPRD (in vitro)

		DSC2	DSG2
Description		desmocollin 2	desmoglein 2
Image
GO Annotations	Cellular Component	Cornified Envelope Plasma Membrane Cell-cell Junction Intercalated Disc Integral Component Of Membrane Desmosome Cytoplasmic Vesicle Extracellular Exosome	Cornified Envelope Plasma Membrane Cell-cell Junction Cell Surface Intercalated Disc Integral Component Of Membrane Cell Junction Desmosome Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication	Calcium Ion Binding Cell Adhesion Molecule Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential	Desmosome Organization Purkinje Myocyte Development Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Pathways		Keratinization Formation of the cornified envelope	Apoptotic cleavage of cell adhesion proteins Keratinization Formation of the cornified envelope RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Bronchopulmonary dysplasia ( 23897914) Metabolite levels ( 23823483) Response to immune checkpoint inhibitors in melanoma (immune-related adverse events) ( 33409738)	Blood protein levels ( 30072576 29875488)
Interacting Genes		12 interacting genes: CDC6 CELF4 CLK1 DSC3 DSG1 DSG2 FHOD3 ITSN1 JUP PKP2 PKP3 RO60	5 interacting genes: DSC1 DSC2 JUP PKP2 PKP3
Entrez ID		1824	1829
HPRD ID		00512	00516
Ensembl ID		ENSG00000134755	ENSG00000046604
Uniprot IDs		A0A3B3ISU0 Q02487	Q14126
PDB IDs		5ERP 5J5J 7A7D	2YQG 5ERD 5J5J 6QNT 6QNU 6SIT 7A7D 7AGF 7AGG
Enriched GO Terms of Interacting Partners?
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