DSC1 and JUP

Number of citations of the paper that reports this interaction (PubMedID 9606214)
62

Data Source:
HPRD (in vitro)

		DSC1	JUP
Description		desmocollin 1	junction plakoglobin
Image
GO Annotations	Cellular Component	Cornified Envelope Plasma Membrane Cell-cell Junction Gap Junction Membrane Integral Component Of Membrane Desmosome Extracellular Exosome Ficolin-1-rich Granule Membrane	Cornified Envelope Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Zonula Adherens Fascia Adherens Focal Adhesion Cytoplasmic Side Of Plasma Membrane Intercalated Disc Actin Cytoskeleton Apicolateral Plasma Membrane Lateral Plasma Membrane Catenin Complex Z Disc Hemidesmosome Desmosome Protein-DNA Complex Specific Granule Lumen Extracellular Exosome Gamma-catenin-TCF7L2 Complex Ficolin-1-rich Granule Lumen
	Molecular Function	Calcium Ion Binding Protein Binding	Transcription Coactivator Activity Structural Molecule Activity Protein Binding Protein Kinase Binding Protein Phosphatase Binding Protein Homodimerization Activity Protein-containing Complex Binding Alpha-catenin Binding Cadherin Binding Cell Adhesion Molecule Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Cytoskeletal Protein-membrane Anchor Activity
	Biological Process	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-cell Adhesion	Positive Regulation Of Cell-matrix Adhesion Desmosome Assembly Cell Migration Regulation Of Cell Population Proliferation Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Blood Vessel Endothelial Cell Migration Skin Development Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Detection Of Mechanical Stimulus Positive Regulation Of DNA-binding Transcription Factor Activity Endothelial Cell-cell Adhesion Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Positive Regulation Of Canonical Wnt Signaling Pathway Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Pathways		Neutrophil degranulation Keratinization Formation of the cornified envelope	Adherens junctions interactions VEGFR2 mediated vascular permeability Neutrophil degranulation Keratinization Formation of the cornified envelope RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOJ GTPase cycle
Drugs			Zinc Zinc acetate
Diseases
GWAS		Multiple sclerosis ( 23412934)	Heel bone mineral density ( 30598549 28869591) Major depressive disorder x sex interaction ( 34099189)
Interacting Genes		8 interacting genes: DSG1 DSG2 DSP JUP PKP1 PKP2 PKP3 UCHL5	53 interacting genes: APC ARHGDIA AXIN1 BIRC2 BRCA1 BTRC CDH1 CDH10 CDH15 CDH2 CDH5 CTNNA1 CTNNA3 CTNNBIP1 CTNND1 DDX6 DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSP EGFR ERBB2 ERBB3 FER FHL2 FYN HSP90AA1 MUC1 NFATC4 NFKBIE NTAQ1 PECAM1 PKD1 PKP2 PKP3 PRR35 PSEN1 PTEN PTPN14 PTPRF PTPRJ PTPRK RIBC2 RSPH14 SRC TBP TCF4 TCF7L2 YJU2B ZFYVE9
Entrez ID		1823	3728
HPRD ID		00511	01414
Ensembl ID		ENSG00000134765	ENSG00000173801
Uniprot IDs		Q08554 Q9HB00	A0A0S2Z487 P14923
PDB IDs		5IRY	3IFQ
Enriched GO Terms of Interacting Partners?
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