DPYD and CSDE1

		DPYD	CSDE1
Description		dihydropyrimidine dehydrogenase	cold shock domain containing E1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	P-body Golgi Apparatus Cytosol Plasma Membrane Cytoplasmic Stress Granule CRD-mediated MRNA Stability Complex
	Molecular Function	Uracil Binding Protein Binding Dihydropyrimidine Dehydrogenase (NADP+) Activity Protein Homodimerization Activity Metal Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	RNA Binding Protein Binding RNA Stem-loop Binding
	Biological Process	Purine Nucleobase Catabolic Process Pyrimidine Nucleobase Catabolic Process Thymine Catabolic Process Uracil Catabolic Process Thymidine Catabolic Process CMP Catabolic Process DCMP Catabolic Process Beta-alanine Biosynthetic Process UMP Catabolic Process DUMP Catabolic Process	Regulation Of Translational Initiation Male Gonad Development Stress Granule Assembly Nuclear-transcribed MRNA Catabolic Process, No-go Decay IRES-dependent Viral Translational Initiation
Pathways		Pyrimidine catabolism
Drugs		(5S)-5-Iododihydro-2,4(1H,3H)-pyrimidinedione NADPH 6-Carboxymethyluracil Flavin adenine dinucleotide Flavin mononucleotide Uracil Eniluracil 5-Iodouracil Gimeracil Tegafur-uracil
Diseases
GWAS		Adult body size ( 32376654) Adverse response to drug ( 30420678) Anthropometric traits (multi-trait analysis) ( 30166351) Anxiety/tension (special factor of neuroticism) ( 30867560) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Body mass index ( 25673413 29273807) Borderline personality disorder ( 28632202) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Daytime nap ( 33568662) Extremely high intelligence ( 29520040) Face memory ( 31596458) Feeling nervous ( 29500382) Gastroesophageal reflux disease ( 31527586) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Irritable mood ( 29500382) Menarche (age at onset) ( 25231870) Metabolite levels ( 23823483) Methadone dose in opioid dependence ( 28115739) Platelet count ( 21507922) Regular attendance at a pub or social club ( 29970889) Schizophrenia ( 25056061 29483656 22688191 30285260 23974872) Serum metabolite levels ( 33031748) Sleep duration ( 30531941) Sleep duration (short sleep) ( 30846698) Triglyceride levels ( 32203549 32154731) Waist-to-hip ratio adjusted for BMI ( 28552196)	Autism ( 24189344)
Interacting Genes		11 interacting genes: CLK1 CPB2 CSDE1 GOPC HPCA KCNJ4 LXN OVGP1 RPS6KA3 SRC SULT2A1	23 interacting genes: C11orf68 CDC7 CTBS DOK1 DPYD ERBB2 FAM9B GCKR GCNT1 GFI1 HID1 HNRNPD IGFBP5 KCNMB4 PABPC1 PCSK7 SH3GLB1 SLIT2 SNRPB2 STT3A SYNCRIP WFS1 WNK1
Entrez ID		1806	7812
HPRD ID		02036	15949
Ensembl ID		ENSG00000188641	ENSG00000009307
Uniprot IDs		Q12882	A0A024R0E2 A0A024R0K2 O75534
PDB IDs			1WFQ 1X65 2YTV 2YTX 2YTY
Enriched GO Terms of Interacting Partners?
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