DPYD and CPB2

		DPYD	CPB2
Description		dihydropyrimidine dehydrogenase	carboxypeptidase B2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Extracellular Region Extracellular Space Extracellular Exosome
	Molecular Function	Uracil Binding Protein Binding Dihydropyrimidine Dehydrogenase (NADP+) Activity Protein Homodimerization Activity Metal Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	Metallocarboxypeptidase Activity Zinc Ion Binding
	Biological Process	Purine Nucleobase Catabolic Process Pyrimidine Nucleobase Catabolic Process Thymine Catabolic Process Uracil Catabolic Process Thymidine Catabolic Process CMP Catabolic Process DCMP Catabolic Process Beta-alanine Biosynthetic Process UMP Catabolic Process DUMP Catabolic Process	Positive Regulation Of Extracellular Matrix Constituent Secretion Proteolysis Blood Coagulation Response To Heat Response To Xenobiotic Stimulus Negative Regulation Of Plasminogen Activation Fibrinolysis Negative Regulation Of Fibrinolysis Cellular Response To Glucose Stimulus Liver Regeneration Negative Regulation Of Hepatocyte Proliferation
Pathways		Pyrimidine catabolism	Metabolism of Angiotensinogen to Angiotensins Regulation of Complement cascade
Drugs		(5S)-5-Iododihydro-2,4(1H,3H)-pyrimidinedione NADPH 6-Carboxymethyluracil Flavin adenine dinucleotide Flavin mononucleotide Uracil Eniluracil 5-Iodouracil Gimeracil Tegafur-uracil	AZD-9684 Prothrombin
Diseases
GWAS		Adult body size ( 32376654) Adverse response to drug ( 30420678) Anthropometric traits (multi-trait analysis) ( 30166351) Anxiety/tension (special factor of neuroticism) ( 30867560) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Body mass index ( 25673413 29273807) Borderline personality disorder ( 28632202) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Daytime nap ( 33568662) Extremely high intelligence ( 29520040) Face memory ( 31596458) Feeling nervous ( 29500382) Gastroesophageal reflux disease ( 31527586) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Irritable mood ( 29500382) Menarche (age at onset) ( 25231870) Metabolite levels ( 23823483) Methadone dose in opioid dependence ( 28115739) Platelet count ( 21507922) Regular attendance at a pub or social club ( 29970889) Schizophrenia ( 25056061 29483656 22688191 30285260 23974872) Serum metabolite levels ( 33031748) Sleep duration ( 30531941) Sleep duration (short sleep) ( 30846698) Triglyceride levels ( 32203549 32154731) Waist-to-hip ratio adjusted for BMI ( 28552196)	Blood protein levels ( 29875488 28240269) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Thrombin-activatable fibrinolysis inhibitor levels ( 29378355)
Interacting Genes		11 interacting genes: CLK1 CPB2 CSDE1 GOPC HPCA KCNJ4 LXN OVGP1 RPS6KA3 SRC SULT2A1	7 interacting genes: A2M C5 DPYD F2 PLG PZP TINAG
Entrez ID		1806	1361
HPRD ID		02036	04374
Ensembl ID		ENSG00000188641	ENSG00000080618
Uniprot IDs		Q12882	A0A087WSY5 Q96IY4
PDB IDs			3D66 3D67 3D68 3LMS 4P10 5HVF 5HVG 5HVH
Enriched GO Terms of Interacting Partners?
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