DPP6 and PRNP

Number of citations of the paper that reports this interaction (PubMedID 15146195)
60

Data Source:
HPRD (in vivo)

		DPP6	PRNP
Description		dipeptidyl peptidase like 6	prion protein
Image
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane	Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Cell Surface Postsynaptic Density Inclusion Body Extrinsic Component Of Membrane Dendrite Anchored Component Of External Side Of Plasma Membrane Nuclear Membrane Terminal Bouton Intracellular Membrane-bounded Organelle Membrane Raft Extracellular Exosome Postsynapse
	Molecular Function	Serine-type Peptidase Activity Dipeptidyl-peptidase Activity Potassium Channel Regulator Activity	Amyloid-beta Binding Protease Binding Copper Ion Binding Calcium Ion Binding Protein Binding Lamin Binding Glycosaminoglycan Binding Microtubule Binding Tubulin Binding Aspartic-type Endopeptidase Inhibitor Activity Type 5 Metabotropic Glutamate Receptor Binding Type 8 Metabotropic Glutamate Receptor Binding Signaling Receptor Activity Identical Protein Binding ATP-dependent Protein Binding Transmembrane Transporter Binding Protein-containing Complex Binding Chaperone Binding Cupric Ion Binding Cuprous Ion Binding
	Biological Process	Proteolysis Protein Localization To Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport	Negative Regulation Of Protein Phosphorylation Cellular Copper Ion Homeostasis Response To Oxidative Stress Cell Cycle Learning Or Memory Long-term Memory Negative Regulation Of Endopeptidase Activity Negative Regulation Of Protein Processing Protein Destabilization Activation Of Protein Kinase Activity Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-2 Production Calcium-mediated Signaling Using Intracellular Calcium Source Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Activated T Cell Proliferation Response To Cadmium Ion Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of T Cell Receptor Signaling Pathway Protein Homooligomerization Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Copper Ion Cellular Response To Xenobiotic Stimulus Positive Regulation Of Protein Targeting To Membrane Modulation Of Age-related Behavioral Decline Dendritic Spine Maintenance Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Neuron Death Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Amyloid-beta Formation Regulation Of Intracellular Calcium Activated Chloride Channel Activity Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Protein Localization To Plasma Membrane Response To Amyloid-beta Cellular Response To Amyloid-beta Regulation Of Calcium Ion Import Across Plasma Membrane Neuron Projection Maintenance
Pathways			NCAM1 interactions Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs			Tetracycline Copper
Diseases
GWAS		Age-related cognitive decline (visuospatial skill) (slope of z-scores) ( 30954325) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30679032) Amyotrophic lateral sclerosis ( 18987618 18057069 18084291) Bitter alcoholic beverage consumption ( 31046077) Bone mineral accretion in asthma (oral corticosteroid dose interaction) ( 26025128) Carotid intima media thickness x smoking interaction ( 32117412) Colorectal cancer (diet interaction) ( 24743840) Gestational age at birth in premature rupture of membrane-initiated deliveries (maternal effect) ( 27490719) Gut microbiota relative abundance (Coprococcus) ( 33208821) Height ( 28552196) LDL levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Lean body mass ( 28552196) Pancreatic cancer ( 20686608) Pelvic organ prolapse ( 26545240) Post bronchodilator FEV1 in COPD ( 26634245) Post-traumatic stress disorder ( 24677629) Problematic alcohol use ( 32451486) QT interval ( 23534349) Regular attendance at a pub or social club ( 29970889) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Tardive dyskinesia ( 21826085) Thalamus volume ( 31530798) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Creutzfeldt-Jakob disease ( 19081515) Creutzfeldt-Jakob disease (sporadic) ( 32949544 25918841) Creutzfeldt-Jakob disease (variant) ( 22137330) KANNO antigen negativity ( 31020675) Platelet aggregation ( 20526338) Prion diseases ( 22210626) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI (smoking interaction) ( 28443625)
Interacting Genes		1 interacting genes: PRNP	97 interacting genes: ABT1 ADAM23 ADAP2 ADRB2 AGO1 AIFM3 APBB1 APLP1 APLP2 APOE ARHGAP15 ATIC BAG6 BAZ2B BRD2 C7orf50 CAV1 CCDC149 CCR1 CIRBP CLSTN1 CLU CNP CNTN1 CRYAB CSN3 CSNK2A1 CSNK2A2 CSNK2B CWC15 DDX47 DNM1 DOCK7 DPP6 DYRK3 ERI3 F2RL1 FAM27E3 FBLN5 FBXO45 FGF13 FHL1 FZD7 GRB2 HAX1 HSPA5 HSPD1 IER3 KIAA1191 KIFAP3 L1CAM LMNA LSAMP MAG MARK4 MMADHC MOG MTG1 NCAM1 NCAM2 NECTIN1 NHP2 NIPSNAP2 NOB1 OPCML P4HB PDE4DIP PLG PPFIBP2 PPP1R14A PSMA3 PSMB5 PTAFR PTRH1 PYM1 RBM22 RNPC3 RPL41 SCNM1 SEC31A SPARCL1 STARD5 STIP1 SURF2 TBPL1 TMEM237 TRIM15 TSC22D4 TSLP TYMSOS UTP4 WDR5 WDR61 ZFYVE28 ZKSCAN8 ZNF408 ZNF740
Entrez ID		1804	5621
HPRD ID		00525	01453
Ensembl ID		ENSG00000130226	ENSG00000171867
Uniprot IDs		A7E2E4 B7Z299 E9PDL2 E9PF59 P42658 Q8IYG9	F7VJQ1 P04156 Q53YK7
PDB IDs		1XFD	1E1G 1E1J 1E1P 1E1S 1E1U 1E1W 1FKC 1FO7 1H0L 1HJM 1HJN 1I4M 1OEH 1OEI 1QLX 1QLZ 1QM0 1QM1 1QM2 1QM3 2IV4 2IV5 2IV6 2K1D 2KUN 2LBG 2LEJ 2LFT 2LSB 2LV1 2M8T 2OL9 2W9E 3HAF 3HAK 3HEQ 3HER 3HES 3HJ5 3HJX 3MD4 3MD5 3NHC 3NHD 3NVF 4DGI 4E1H 4E1I 4KML 4N9O 5L6R 5YJ4 5YJ5 6DU9 6LNI 6PQ5 6PQA 6SUZ 6SV2 6UUR
Enriched GO Terms of Interacting Partners?
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