DPH2 and IL17A

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		DPH2	IL17A
Description		diphthamide biosynthesis 2	interleukin 17A
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Extracellular Region Extracellular Space External Side Of Plasma Membrane
	Molecular Function	Protein Binding 2-(3-amino-3-carboxypropyl)histidine Synthase Activity	Cytokine Activity Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Peptidyl-diphthamide Biosynthetic Process From Peptidyl-histidine	Positive Regulation Of Antimicrobial Peptide Production Adaptive Immune Response Apoptotic Process Inflammatory Response Immune Response Notch Signaling Pathway Cell-cell Signaling Cell Death Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-16 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Innate Immune Response Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Intestinal Epithelial Structure Maintenance Cellular Response To Interleukin-1 Fibroblast Activation Interleukin-17-mediated Signaling Pathway Granulocyte Migration Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
Pathways		Synthesis of diphthamide-EEF2	Interleukin-17 signaling Interleukin-4 and Interleukin-13 signaling
Drugs			Secukinumab Ixekizumab
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026)	Height ( 28552196)
Interacting Genes		8 interacting genes: BEST4 CRYGA FARS2 IL17A MAGOH MISP NEK6 TNK2	3 interacting genes: DPH2 IL17RA KCNIP4
Entrez ID		1802	3605
HPRD ID		16023	04396
Ensembl ID		ENSG00000132768	ENSG00000112115
Uniprot IDs		B3KRB8 Q9BQC3	Q16552
PDB IDs			2VXS 4HR9 4HSA 4QHU 5HHV 5HHX 5HI3 5HI4 5HI5 5N7W 5N92 5NAN 5VB9 6WIO 6WIR
Enriched GO Terms of Interacting Partners?
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