DMD and SGCZ

Number of citations of the paper that reports this interaction (PubMedID 12189167)
19

Data Source:
HPRD (in vitro)

		DMD	SGCZ
Description		dystrophin	sarcoglycan zeta
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Plasma Membrane Cell Surface Dystrophin-associated Glycoprotein Complex Syntrophin Complex Lateral Plasma Membrane Z Disc Cell Junction Cell-substrate Junction Filopodium Cortical Actin Cytoskeleton Filopodium Membrane Protein-containing Complex Sarcolemma Cell Projection Costamere Neuron Projection Terminus Membrane Raft Synapse Postsynaptic Membrane	Cytoplasm Cytoskeleton Sarcoglycan Complex Integral Component Of Membrane Sarcolemma
	Molecular Function	Dystroglycan Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Zinc Ion Binding Structural Constituent Of Muscle Myosin Binding Vinculin Binding Nitric-oxide Synthase Binding Actin Filament Binding
	Biological Process	Regulation Of Heart Rate Cytoskeleton Organization Muscle Organ Development Skeletal Muscle Tissue Development Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Regulation Of Skeletal Muscle Contraction Actin Cytoskeleton Organization Negative Regulation Of Peptidyl-serine Phosphorylation Cellular Protein Localization Cellular Protein-containing Complex Assembly Maintenance Of Blood-brain Barrier Response To Muscle Stretch Peptide Biosynthetic Process Muscle Cell Cellular Homeostasis Neuron Development Muscle Cell Development Cardiac Muscle Contraction Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cardiac Muscle Cell Action Potential Regulation Of Muscle System Process Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Peptidyl-cysteine S-nitrosylation Positive Regulation Of Sodium Ion Transmembrane Transporter Activity	Muscle Cell Cellular Homeostasis Cardiac Muscle Tissue Development Muscle Cell Development Heart Contraction Membrane Organization
Pathways		Non-integrin membrane-ECM interactions Striated Muscle Contraction
Drugs		Golodirsen
Diseases
GWAS		Ankle-brachial index ( 31388106) Anxiety in major depressive disorder ( 24047446) Body mass index ( 28892062) Influenza A (H1N1) infection ( 26379185) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Major depressive disorder ( 34099189) Mild influenza (H1N1) infection ( 26379185) Response to anti-depressant treatment in major depressive disorder ( 22041458) Temporomandibular joint disorder ( 28081371) Waist circumference ( 28552196)	Adult body size ( 32376654) Body mass index ( 25673413) Cleft lip with or without cleft palate (maternal periconceptional vitamin use interaction) ( 29535761) Depressive symptom improvement ( 30468137) Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Endometrial cancer (Non-endometrioid histology) ( 30093612) Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042) General cognitive ability ( 29844566) HDL cholesterol levels ( 32203549) Height ( 28552196) Intelligence (MTAG) ( 29326435) Joint damage in rheumatoid arthritis ( 31596875) Methamphetamine dependence ( 23594818) Neurociticism ( 29500382) Obesity-related traits ( 23251661) Platelet aggregation ( 20526338) Retinitis pigmentosa ( 33514863) Small cell lung carcinoma ( 28604730) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		30 interacting genes: ACTA1 ACTC1 APP CADPS CADPS2 CDC25A CTNNAL1 DAG1 DGKZ DISC1 DTNA DTNB FASLG HAUS1 HNF4A KCNJ12 KRT19 KRT8 MAP3K5 PGM5 PICK1 SGCZ SNTA1 SNTB1 SNTB2 SNTG1 SNTG2 TRAF3IP1 TRIM63 UTRN	3 interacting genes: DMD SGCB SMIM3
Entrez ID		1756	137868
HPRD ID		02303	12165
Ensembl ID		ENSG00000198947	ENSG00000185053
Uniprot IDs		A0A0S2Z3B5 A0A0S2Z3J7 A7E212 P11532 Q16484 Q4G0X0	Q08AT0 Q96LD1
PDB IDs		1DXX 1EG3 1EG4 3UUN
Enriched GO Terms of Interacting Partners?
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