LRATD2 and PALB2

Number of citations of the paper that reports this interaction (PubMedID 25640309)
8

Data Source:
BioGRID (two hybrid)

		LRATD2	PALB2
Description		LRAT domain containing 2	partner and localizer of BRCA2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane	Nucleoplasm Protein-containing Complex
	Molecular Function	Protein Binding	DNA Binding Protein Binding
	Biological Process		Double-strand Break Repair Via Homologous Recombination Somitogenesis Inner Cell Mass Cell Proliferation Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development
Pathways			HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Drugs
Diseases
GWAS			Bipolar disorder ( 17554300)
Interacting Genes		14 interacting genes: ADRB2 AP1M1 BAG4 CTNNA1 DDIT4L ESR2 FGFR4 NOTCH2 PALB2 PTPN1 SMAD4 TAX1BP1 UROD XRCC3	32 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 H2BC3 H3C1 H4C1 HNRNPC IL13RA2 IL24 KEAP1 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 XRCC3
Entrez ID		157638	79728
HPRD ID		11403	07966
Ensembl ID		ENSG00000168672	ENSG00000083093
Uniprot IDs		Q96KN1	H3BN63 Q86YC2
PDB IDs			2W18 3EU7
Enriched GO Terms of Interacting Partners?
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